Supply 99% CAS 153439-40-8 Fexofenadine Hcl Fexofenadine Hydrochloride Powder

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What's CAS 153439-40-8 Fexofenadine Hcl Powder ？

Product Name	Fexofenadine hydrochloride/Fexofenadine hcl
Other names	Fexofenadine hydrochloride,Fexofenadine hydrochloride powder,Fexofenadine hydrochloride price, Fexofenadine hydrochloride  powder price,Fexofenadine hydrochloride factory, Fexofenadine hydrochloride powder price, Fexofenadine hcl powder, Fexofenadine hcl price,Fexofenadine hcl powder price
CAS NO	153439-40-8
Molecular Formula	C32H40ClNO4
Molecular Weight	538.12
Appearance	White powder

Fexofenadine hydrochloride (trade name: Allegra) belongs to a second-generation antihistamine

pharmaceutical drug. It is mainly used for the treatment of allergy symptoms including watery eyes, hay

fever, nasal congestion, urticaria, runny nose, itching eyes/nose, sneezing, hives, and itching. It is a kind of

selectively peripheral H1 blocker.

 

Its mechanism of action in vivo is through preventing the histamine-mediated activation of the H1 receptors,

thus alleviating the symptoms related to allergy. Compared to the first-generation antihistamine drug, it is

less prone to penetrate the blood-brain barrier, reducing the possibility to cause side effects such as drowsiness.

 

 

Application & Function

Fexofenadine is a non-sedating antihistamine that selectively antagonizes the histamine H1 receptor with a Ki

value of 10 nM and exhibits anti-inflammatory effects. It is devoid of central nervous system effects in part

because it is a good substrate for the P-glycoprotein efflux pump situated within the blood-brain barrier.

 

Fexofenadine is used for relief from physical symptoms associated with seasonal allergic rhinitis and for

treatment of chronic urticaria. It does not cure but rather prevents the aggravation of allergic rhinitis and

chronic idiopathic urticaria and reduces the severity of the symptoms associated with those conditions,

providing relief from repeated sneezing, runny nose, itchy eyes or skin, and general body fatigue.

 

Item	Requirement	Results
Description	White to off-white powder or crystalline powder; bitter taste, odorless	White crystalline powder
chloride	The solution gives reaction of chloride	complies
HPLC	The retention time of the main peak of the test solution corresponds to that of reference peak	complies
IR	The infrared spectrum of the testing solution corresponds to that of reference solution	complies
Residual on ignition	≤0.1% max	0.06%
Heavy metals	Not more than 0.2%	complies
Impurity B	Not more than 0.2%	Not detected
Water	Not more than 0.5%	0.34%
Impurity A	Not more than 0.2%	0.03%
decarboxylated degradant	Not more than 0.15%	0.05%
Single impurity	Not more than 0.1%	0.06%
Total impurities	Not more than 0.5%	0.2%
Content of chloride	6.45%~6.75%	6.52%
Assay(Calculated on the anhydrous basis)	Not less than98.0% and Not more than102.0%	99.6%
Conclusion:meet the USP Standard

 

 

 

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Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,

constantly strict requirements, set goals, and implement win-win development.

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