AMMONIUM NIOBATE(V) OXALATE HYDRATE 99&

Superiority:

Product Name:    tert-Butyldimethylsilyl chloride
Synonyms:    t-butylchlorodimethyl-silan;SILANE TBM2;SILANE, CHLORO(1,1-DIMETHYLETHYL)DIMETHYL-;T-BUTYLDIMENHYLSILYL CHLORIDE;t-butyl dimethyl chlorsilane;T-BUTYLDIMETHYLCHLOROSILANE;T-BUTYLDIMETHYLSILYL CHLORIDE;TBDMSCI
CAS:    18162-48-6
MF:    C6H15ClSi
MW:    150.72
EINECS:    242-042-4
Product Categories:    Pharmaceutical intermediates;Organics;Alkyldimethylsilylation (GC Derivatizing Reagents);organosilicon compounds;Miscellaneous Reagents;pharma material;FINE Chemical & INTERMEDIATES;blocks;BuildingBlocks;Coupling Reagent;N-Protecting Reagents;Protecting and Derivatizing Reagents;Protection and Derivatization;Silicon-Based;Analytical Chemistry;Biochemistry;GC Derivatizing Reagents;Monochlorosilanes;Nucleosides, Nucleotides & Related Reagents;Protecting Agents for Hydroxyl and Amino Groups;Protecting Agents, Phosphorylating Agents & Condensing Agents;Protection & Derivatization Reagents (for Synthesis);Reagents for Oligosaccharide Synthesis;Si (Classes of Silicon Compounds);Si-Cl Compounds;Silicon Compounds (for Synthesis);Blocking Agents;Chloro Silanes;Protective Agents;Silylating Agents;Silylation (GC Derivatizing Reagents);Synthetic Organic Chemistry
Mol File:    18162-48-6.mol

Melting point     86-89 °C (lit.)
Boiling point     125 °C (lit.)
density     0.87 g/mL at 20 °C(lit.)
refractive index     n20/D 1.46
Fp     73 °F
storage temp.     Store at 5°C
form     Liquid
color     Clear colorless
Specific Gravity    1.225
Water Solubility     Soluble in chloroform and ethyl acetate. Insoluble in water.
Sensitive     Moisture Sensitive
Hydrolytic Sensitivity    7: reacts slowly with moisture/water
Hydrolytic Sensitivity    8: reacts rapidly with moisture, water, protic solvents
BRN     505999
InChIKey    BCNZYOJHNLTNEZ-UHFFFAOYSA-N
CAS DataBase Reference    18162-48-6(CAS DataBase Reference)
NIST Chemistry Reference    Silane, chloro(1,1-dimethylethyl)dimethyl-(18162-48-6)
EPA Substance Registry System    Silane, chloro(1,1-dimethylethyl)dimethyl- (18162-48-6)
Safety Information
Hazard Codes     C,F,T,Xn
Risk Statements     22-35-40-34-10-19-11-67-65-63-48/20-20/21/22-45-23/24/25-37-36/37/38
Safety Statements     26-36/37/39-46-62-45-25-16-28-27-33-29-53-36/37
RIDADR     UN 2925 4.1/PG 2
WGK Germany     2
RTECS     VV2000000
F     10-21
Hazard Note     Flammable/Corrosive/Moisture Sensitive
TSCA     Yes
HazardClass     4.1
PackingGroup     III
HS Code     29310095
MSDS Information
Provider    Language
TBDMCS    English
SigmaAldrich    English
ACROS    English
ALFA    English
tert-Butyldimethylsilyl chloride Usage And Synthesis
Introduction    Triethylchlorosilane is a clear, colourless to yellowish, pungent smelling, caustic and flammable liquid. It can be dissolved in non-protonating solvents without decomposition.
It may be used as silylating agent for dervatization of primary and secondary alcohols etc.. Also it may be used to protect allylic esters as silylketene acetal which is ore stable but less volatile derivates than trimethylchlorosilane.
Chemical Properties    White solid
Uses    Used to protect alcohols during organic synthesis.
Definition    ChEBI: A silyl chloride consisting of a central silicon atom covalently bound to one chloro, one tert-butyl and two methyl groups. tert-Butyldimethylsilyl chloride is a derivatisation agent used in gas chromatography/mass spectrometry ap lications.
Hazard    Moderately toxic.
Purification Methods    Fractionally distil it at atmospheric pressure. [Sommer & Tyler J Am Chem Soc 76 1030 1954, Corey & Venkateswarlu J Am Chem Soc 94 6190 1972, Beilstein 4 IV 4076.]
tert-Butyldimethylsilyl chloride Preparation Products And Raw materials
Raw materials    Pentane-->tert-Butyllithium-->Dichlorodimethylsilane
Preparation Products    5-(AMINOMETHYL)-1-METHYLPYRROLIDIN-2-ONE-->(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one-->beta-Methyl vinyl phosphate (MAP)-->2-CYANOPYRIDINE-4-CARBOXALDEHYDE-->4-(HYDROXYMETHYL)PICOLINITRILE-->Simvastatin-->2-Chloro-4-nitrophenyl-alpha-L-fucopyranoside-->4-Mercaptophenylboronic acid-->Montelukast-->Trifluoromethanesulfonic acid tert-butyldimethylsilyl ester-->Calcipotriene-->BIS(T-BUTYLDIMETHYLSILOXY)ETHANE