2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL

Superiority:

Product Name:    2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL
Synonyms:    2-DI-T-BUTYLPHOSPHINO-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL;2-Di-tert-butylphosphino-2',4',6'-trisopropylbinphenyl;tBuXPhos 97%;2-Di-tert-butyL;phosphino-2',4',6'-triisopropyL;phosphine, bis(1,1-diMethylethyl)[2',4',6'-tris(1-Methylethyl)[1,1'-biphenyl]-2-yl]-;t-Bu XPhos;tBuXPhos
CAS:    564483-19-8
MF:    C29H45P
MW:    424.64
EINECS:    639-817-8
Product Categories:    Achiral Phosphine;Aryl Phosphine;Buchwald Ligands Series;Buchwald Ligands&Precatalysts
Mol File:    564483-19-8.mol

Melting point     148-151 °C(lit.)
Boiling point     493.5±45.0 °C(Predicted)
form     Crystalline Powder
color     White
InChIKey    SACNIGZYDTUHKB-UHFFFAOYSA-N
Safety Information
Hazard Codes     Xi
Risk Statements     36/37/38
Safety Statements     26-36/37/39
WGK Germany     3
TSCA     No
HS Code     29310099
MSDS Information
Provider    Language
SigmaAldrich    English
2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL Usage And Synthesis
Uses    tBuXPhos [2-Di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions. tBuXPhos has been used in the preparation of [tBuXPhosAu(MeCN)]BAr4F, a gold catalyst for the intermolecular [2+2] cycloaddition of terminal arylalkynes with substituted alkenes to form functionalized cyclobutenes with high regioselectivity.
tBuXPhos is a ligand for Pd-catalyzed C-O and C-N bond formation.
It can be used in the following reactions:
• Palladium-catalyzed Tsuji-Trost substitution and cross-coupling of benzylic fluorides.
• Palladium-catalyzed C-N cross-coupling of sulfinamides and aryl halides.
• Palladium-catalyzed rapid methoxylation and deuteriomethoxylation of bromo-chalcones.
Reactions    
Effective ligand for the Pd-catalyzed arylation of pyrazoles, indazoles and amino heterocycles.
Ligand used in the Pd-catalyzed synthesis of phenols from aryl halides and KOH.
Ligand used in the Pd-catalyzed of benzoic acids from aryl halides and CO2.
Ligand used in the Pd-catalyzed trifluoromethylation of vinyl sulfonates.
Ligand used in the Pd-catalyzed arylation of nitroacetates.
Ligand used in the Pd-catalyzed Suzuki−Miyaura cross-coupling of allylboronates and aryl halides.
Ligand used in the Pd-catalyzed cyanation of (hetero)arylchlorides and bromides.
Ligand used in the Pd-catalyzed C–N cross coupling of sulfinamides and aryl halides.
Ligand used in the Pd-catalyzed arylation of cyanamides. 

Chemical Properties    White to pale yellow
Uses    Effective ligand for the Pd-catalyzed arylation of pyrazoles, indazoles and amino heterocycles
Uses    suzuki reaction
2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL Preparation Products And Raw materials
Raw materials    Ethyl acetate-->Tetrahydrofuran-->DCM-->Government regulation-->Benzene-->Aluminum chloride-->Carbon tetrachloride-->Iron-->Magnesium-->Phosphorus trichloride-->Copper(I) chloride-->1,2-Dibromoethane-->2-Bromopropane-->2-Chloro-2-methylpropane-->1,2-Dibromobenzene