Details:

Product name: avibactam sodium
CAS No:1192491-61-4
Appearance: white powder
Molecular weight: 287.226
Molecular formula:C7H10N3NaO6S
Usage: Avibactam sodium is a covalent and reversible β-lactamase inhibitor, inhibits β-lactamase TEM-1 and CTX-M-15 with IC50 of 8 nM and 5 nM, respectively.
Assay: HPLC; HNRM; LC-MS
[Solubility]:Soluble in ethanol,chloroform,propylene glycol and ethylenediamine. Slightly soluble in diethyl ether. Partly soluble in water.
[Specs] NLT 99%, Food Grade, Pharmaceutical Grade
Capacity: 1000kgs per month
Source: synthetic
Place of Origin: China Yinherb-Lab
Packing: As per client's requirements
Minimum Order Quantity: 1kg
Storage: Store in cool & dry place, Keep away from strong light and heat.
 

What is Avibactam/NXL-104
Avibactam is a non-β-lactam β-lactamase inhibitor developed by Actavis (now Allergan) jointly with AstraZeneca. A new drug application for avibactam in combination with ceftazidime (branded as Avycaz) was approved by the FDA on February 25, 2015, for treating complicated urinary tract (cUTI) and complicated intra-abdominal infections (cIAI) caused by antibiotic resistant-pathogens, including those caused by multi-drug resistant Gram-negative bacterial pathogens.

Avibactam/NXL-104 Benefits

The -lactamase serine nucleophilic attack avibatanamide bond, open loop to form a covalent bond, the enzyme - inhibitor complex, as an enzyme inhibition form, without hydrolysis, and then cyclization to form a lactam ring to get Avibatan Chemicalbook tan. The nucleophilic attack leads to the rate of ring-opening much higher than that of cyclization, resulting in the inhibition of-lactamase. In this process, the structure of Avibatan itself can be restored by the reverse reaction, so it has a long-term inhibitory effect.
It is one of the most promising new -lactamase inhibitors. Compared with the three listed -lactamase inhibitors, they are long-acting and covalently binding to enzyme reversibility, and do not induce -lactamase production.

 

Q: What's your MOQ
A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.

Q: Is there a discount
A: Yes, for larger quantity, we always support with better price. 

Q: How to confirm the Product Quality before placing orders
A: You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests

Q: How to start orders or make payments
A: You can send our your Purchase order (if your company has), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.

Q: How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.