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157115-85-0 Wholesaler 157115-85-0 reasonable price Noopept (GVS111) factory
Noopept (GVS111) factory 157115-85-0 Wholesaler reasonable price
NooglutilexhibitspharmacologicallysignificantcompetitionwithaselectiveagonistofAMPAreceptors([G-3H]Ro48-8587)forthereceptorbindingsites(withIC50=6.4+/-0.2microM),whilethecompetitionofnoopeptforthesereceptorbindingsiteswaslowerbyanorderofmagnitude(IC50=80+/-5.6microM).GVS111significantlyincreasedneuronalsurvivalafterH(2)O(2)treatmentdisplayingadosedependentneuroprotectiveactivityfrom10nMto100microM,andanIC(50)valueof1.21+/-0.07microM.GVS111inhibitedtheaccumulationofintracellularfreeradicalsandlipidperoxidationdamageinneuronstreatedwithH(2)O(2)orFeSO(4),suggestinganantioxidantmechanismofaction
N-Phenylacetyl-L-prolylglycineethylester(GVS-111)administeredintravenouslyatadoseof0.5mg/kg/day,forthefirsttime1hafterischaemiclesionandthenfor9post-operativedays,withthelastadministration15minbeforetesting,attenuatedthedeficit[3].GVS-111itselfwasnotfoundinratbrain1hafter5mg/kgi.p.administrationuptolimitofdetection(LOD)underhighperformanceliquidchromatography(HPLC)conditions.Themostpronouncedantiinflammatoryeffectofdipeptidewasobservedonthemodelofadjuvantarthritisinrats,wherethedrugadministeredover25daysinadailydoseof0.5mg/kg(i.m.)or5mg/kg(p.o.)significantlyreducedthechronicimmuneinflammation(onthe12thday,by94.0and74.1%,respectively)
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