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Exemestane manufacturer Exemestane low price supplier 107868-30-4
manufacturer Exemestane low price supplier 107868-30-4
The growth of breast cancer cells can depend on the presence of estrogen, and the estrogens (estrogen and estradiol) in a woman's postmenopausal cycle are mainly converted by aromatic enzymes in peripheral tissues to the androgens (androdiketones and testosterone) in the adrenal glands and ovaries. Stopping estrogen production by inhibiting aromatase is an effective selective treatment for postmenopausal hormone-dependent breast cancer. Isimetan is an irreversible steroidal aromatase inactivator, similar in structure to the enzyme's natural substrate, and is a pseudo-substrate of aromatase, which can be inactivated by irreversibly binding to the active site of the enzyme, thereby significantly reducing the level of estrogen in the blood circulation of menopausal women, but without significant effect on the biosynthesis of corticosteroids and aldosterone in the adrenal glands. At 600 times higher than the concentration of inhibiting aromatase action, there was no significant effect on other enzymes in the steroid-producing pathway.
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