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1379686-30-2 Wholesaler 1379686-30-2 low price SR9009 ?factory sells
Wholesaler 1379686-30-2 low price SR9009 factory sells
In vitro studies
SR9009 has a lethal effect on cancer cells and senescent cells (including melanocytic nevi) induced by oncogenes, but has no effect on the viability of normal cells and tissues. SR9009 can regulate autophagy and lipid neoplasia, which plays a key role in inducing apoptosis in malignant cells. The cancer cells were treated with SR9009. By detecting the splicing of caspase3 and the TUNEL test, the treatment of SR9009 cancer cells reduced their cell viability because the apoptosis response was induced. SR9009 reduces the number of autophagosomes, thereby inhibiting autophagy.
In vivo research
In food-borne obese rats, SR9909 can cause a decrease in fat mass and blood lipids. In vivo, SR9009 can inhibit the growth of malignant glioma and improve its survival rate in mice without causing significant toxicity. SR9009 can penetrate the blood-brain barrier. In a transplanted tumor model constructed with a malignant glioma taken from a patient, SR9009 inhibits tumor growth. In two different models of malignant glioma, the survival rate was significantly improved.
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