Supply 98% CAS 138112-76-2 Agomelatine Powder

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What's CAS 138112-76-2 Agomelatine Powder ？

Product name	Agomelatine Powder
CAS	138112-76-2
MF	C15H17NO2
Appearance	White Crystalline Powder
Assay	99.5~100.5%

Agomelatine's unique pharmacology and favorable side effect profile make it a boon for depressed patients, especially those who

have not responded to conventional antidepressants.

 

Valdoxan tablets contain the active ingredient agomelatine, which is a type of medicine called an antidepr

essant. It is used to treat depression.

Agomelatine acts on the melatonin and serotonin receptors in the brain.

Melatonin is a hormone made by the pineal gland, a structure in the brain. It is normally released soon after it starts to get dark.

The amount produced then increases until about four am, before dropping off again. Melatonin is linked with the control of circadian

rhythms and promoting sleep. It works by acting on melatonin receptors in the brain.

Agomelatine mimics the action of melatonin and helps to re-synchronise the body's circadian rhythms. These include mood, anxiety, appetite,

body temperature and sleep/wake cycles. These circadian rhythms, particularly sleep cycles, are severely disturbed in people with depression.

Agomelatine's main action is to improve the onset and quality of sleep and this in turn has an antidepressant effect.

Agomelatine also helps to improve mood in depression by increasing noradrenaline and dopamine release in the brain. These are natural

chemicals called neurotransmitters that are involved, amongst other things, in regulating mood.

 

Agomelatine is indicated for the treatment of major depressive episodes in adults.Ten placebo controlled trials have been performed to investigate

the short term efficacy of agomelatine in major depressive disorder. At the end of treatment, significant efficacy was demonstrated in six of the ten

short-term double-blind placebo-controlled studies.Two were considered "failed" trials, as comparators of established efficacy failed to differentiate

from placebo. Efficacy was also observed in more severely depressed patients in all positive placebo-controlled studies.The maintenance of antidepressant

efficacy was demonstrated in a relapse prevention study.

 

Items	Specifications	Results
Appearance	White or almost white powder	Conforms
Identification
A: IR Spectrum	A: Sample IR spectrum comparable with that of the standard	Conforms
B: Chloride	B: Positive	Conforms
pH	4.0~6.5	5.92
Impurity E (by TLC)	NMT0.5%	<0.5%
Loss on drying	NMT0.5%	0.03%
Heavy Metals	NMT20ppm	<20ppm
Related Compounds	Impurity A: NMT1.0%	ND
	Impurity B: NMT0.5%	ND
	Impurity C: NMT0.2%	0.04%
	Impurity D: NMT0.1%	ND
	Any other impurity : NMT1.0%	0.03%
	Total impurity: NMT1.0%	0.07%
Residual Solvents
Ethanol	NMT 1000ppm	314ppm
Isopropanol	NMT 1000ppm	13ppm
DIchloromethane	NMT 300ppm	2ppm
Assay by HPLC	97.0%~102.0%	100.10%
Conclusion	The product meets USP Specifications

 

 

 

1. All inquiries will be replied within 12 hours.

2. Dedication to quality, supply & service.

3. Strictly on selecting raw materials.

4. OEM/ODM Available.

5. Reasonable & competitive price, fast lead time.

6. Sample is available for your evaluation & Formulation development.

7. Faster delivery:Sample order in stock and 3-7 days for bulk production.

8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder

9. After-Sale Service:
1) International Authorized Third-Party Test For The Products You Demand.

2) 30 Days Warranty of quality of goods. 

 

Delivery & Payment Terms

Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,

constantly strict requirements, set goals, and implement win-win development.

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