Entecavir Best price Buy 209216-23-9 High quality

Details:

Product Description

Entecavir is an antiviral nucleoside analog of 2'-deoxyguanosine (Item No. 9002864) and inhibitor of hepatitis B virus (HBV) reverse transcriptase (IC₅₀ = 0.5 nM). It undergoes phosphorylation by cellular kinases to its active form, entecavir triphosphate. Entecavir reduces virion DNA in the culture supernatant of HepG2 2.2.15 cells infected with hepatitis B virus (HBV; EC₅₀ = 3.75 nM). It reduces serum and hepatic levels of viral DNA in a duckling model of HBV infection when administered at a dose of 1 mg/kg. Formulations containing entecavir have been used in the treatment of chronic HBV infection.

Technical Information

Formal Name

2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one, monohydrate

CAS Number

209216-23-9

Synonyms

• BMS 200475
• SQ 34,676

Molecular Formula

C₁₂H₁₅N₅O₃ • H₂O

Formula Weight

295.3

Purity

≥95%

Formulation

A crystalline solid

Solubility

• DMF: 14 mg/ml
• DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml
• DMSO: 12 mg/ml
• Ethanol: 0.1 mg/ml

λ_max

256 nm

SMILES

NC(NC1=C2N=CN1[C@H]3C[C@H](O)[C@@H](CO)C3=C)=NC2=O.O

InChi Code

InChI=1S/C12H15N5O3.H2O/c1-5-6(3-18)8(19)2-7(5)17-4-14-9-10(17)15-12(13)16-11(9)20;/h4,6-8,18-19H,1-3H2,(H3,13,15,16,20);1H2/t6-,7-,8-;/m0./s1

InChi Key

YXPVEXCTPGULBZ-WQYNNSOESA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room Temperature in continental US; may vary elsewhere

Stability

≥ 2 years