exemestane CAS:107868-30-4 Aromasin
exemestane powder
product name: exemestane
cas number: 107868-30-4
superlist name: exemestane
molecular structure: molecular structure of 107868-30-4 (6-methyleneandrosta-1,4-diene-3,17-dione)
formula: c20h24o2
function
exemestane (trade name aromasin) is a drug used to treat breast cancer. it is a member of the class of drugs known as aromatase inhibitors. some breast cancers require estrogen to grow. those cancers have estrogen receptors (ers), and are called er-positive. they may also be called estrogen-responsive,hormonally-responsive, hormone-receptor-positive. aromatase is an enzyme that synthesizes estrogen. aromatase inhibitors block the synthesis of estrogen. this lowers the estrogen level, and slows the growth of cancers.
application
1. exemestane is an oral steroidal aromatase inhibitor that is used in er-positive breast cancer in addition to surgery and/or radiation in post-menopausal women.
2. it acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as "suicide inhibition."
3. by being structurally similar to enzyme targets, exemestane permanently binds to the enzymes, preventing them from converting androgen into estrogen
Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, steroids, pharmaceutical intermediates, chemical solvents, pesticide intermediates, OLED intermediates and other fine chemicals.
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