Details:

Best Quality 99% Fursultiamine Powder CAS 804-30-8

Product information

      Furanthiamine is a white or yellowish crystalline powder.Furanthiamine is a derivative of vitamin B1, also known as long-acting vitamin B1, suitable for the treatment of vitamin B1 deficiency of beriberi or Wernicke encephalopathy, can also be used for vitamin B1 deficiency caused by peripheral neuritis, dyspepsia and other adjuvant therapy.

Product Function/Application:

1.Fursultiamine, a vitamin B1 derivative, enhances chondroprotective effects of glucosamine hydrochloride and chondroitin sulfate in rabbit experimental osteoarthritis

2.Object and design: The therapeutic effect of glucosamine hydrochloride (GH) and chondroitin sulfate (CS) in combination with fursultiamine, a vitamin B 1 derivative, on the development of cartilage lesions was investigated in an animal model of osteoarthritis (OA). 
Methods: The OA model was created by partial medial meniscectomy of the right knee joint (day 0). The rabbits were placed into three experimental groups: operated (OA) rabbits that received placebo treatment, OA rabbits that received GH (1000 mg/kg) + CS (800 mg/kg), and OA rabbits that received GH + CS + fursultiamine (100 mg/kg). Each treatment was initiated on day 3 and continued for 8 weeks. Macroscopic and histologic analyses were performed on the cartilage. The level of MMP-1 in OA cartilage chondrocytes was evaluated by immunohistochemistry. 
3.Results: Only the group receiving combined treatment with GH + CS +fursultiamine showed a significant reduction in the severity of macroscopic and histologic lesions on tibial plateau, which is the weight bearing cartilage surface of the tibia, compared with placebo-treated OA rabbits. This treatment group also revealed a small, but significant, decrease in the body weight gain of the rabbits. In cartilage from placebo-treated OA rabbits, a significantly higher percentage of chondrocytes in superficial layer stained positive for MMP-1 compared with unoperated control. Rabbits treated with the GH + CS + fursultiamine revealed a significant reduction in the level of MMP-1. Conclusion: These results suggest that the chondroprotective effect of GH + CS is enhanced by the addition of fursultiamine in experimental OA. This effect was associated with a reduction in the level of MMP-1, which are known to play an important role in the pathophysiology of OA lesions.

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FAQ:

Q1: Can I get some samples
A: Yes, free samples(5-10g or enough to detection) are available for most of our products, you only need to pay the shipping cost.

Q2: How to confirm the quality before orders
A: Two ways, either by free samples, or send us the detailed specifications, we will arrange the production as per your 
requirement.

Q3: What's your MOQ
A: Normally 1 kg, but smaller quantity is also acceptable for some special products.
 
Q4: How about discount
A: Mainly based on quantity, also some promotional products with special discount from time to time.

Q5. What's the delivery lead time
A: 2-3 working days after payment.
 
Q6: How to make order & payment
A: Proforma invoice will be sent after your confirmation of the order, We can accept payment by T/T, ,Transfer Wise and MoneyGram.