Reliable quality 404-86-4 Capsaicin in bulk supply 404-86-4 exporter Capsaicin Powder

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Reliable quality 404-86-4 Capsaicin in bulk supply 404-86-4 exporter Capsaicin Powder

Capsaicin is the ingredient found in different types of hot peppers, such as cayenne peppers, that makes the peppers spicy hot. Prototype vanilloid receptor agonist (pEC?? values are 7.97 and 7.10 at rat and human VR1 receptors respectively). Activates sensory neurons that give rise to unmyelinated C-fibers, many of which contain substance P. Topical application desensitizes the sensory nerve endings giving a paradoxical antinociceptive effect.

Technical Information

Formal Name

N-[(4-hydroxy-3-methoxyphenyl)methyl]-6E-8-methyl-nonenamide

CAS Number

404-86-4

Molecular Formula

C₁₈H₂₇NO₃

Formula Weight

305.4

Purity

≥95%

Formulation

A crystalline solid

Solubility(Learn about Variance in Solubility)

• DMF: 50 mg/ml
• DMSO: 30 mg/ml
• Ethanol: 50 mg/ml
• PBS (pH 7.2): 0.1 mg/ml

λ_max

230, 281 nm

SMILES

COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O

InChi Code

InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+

InChi Key

YKPUWZUDDOIDPM-SOFGYWHQSA-N

Origin

Plant/Capsicum

Shipping & Storage Information

Storage

-20°C

Shipping

Room Temperature in continental US; may vary elsewhere

Stability

≥ 2 years

Anticancer Research

Capsaicin is the major pungent ingredient in red and green chili pepper. It is reportedto induce apoptosis selectively in cancer cells and can suppress the activation ofNF-κB through suppression of NF-κB inhibitor IκBα (Aggarwal and Shishodia 2004). It shows anticancer effects in animal models and suppresses carcinogenesisin colon, skin, lung, tongue, and prostate cancers by altering the metabolism ofcarcinogens. It selectively suppresses the human cancer cell growth of prostate,leukemic, glioma, gastric, and hepatic cancers. It inhibited the tumorigenesis linkedand IL-6-induced activation of STAT-3 and STAT3-regulated gene products likecyclin D1, Bcl-2, Bcl-xL, survivin, and VGEF. It arrests cells in G1 phase andinduces apoptosis