75330-75-5 in stock Lovastatin High quality Monacolin K on hot selling

Details:

75330-75-5 in stock Lovastatin High quality Monacolin K on hot selling

A cholesterol lowering drug and a competitive inhibitor of HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids.

An anti-hypercholesterolemic agent that inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. Has been shown to block a series of biological events including: the activation of p21^ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes; the farnesylation of p21^ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin); and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G₁ phase through inhibition of proteasome. Has recently been shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and to block the transcription of type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF. This product requires activation for use in cell synchronization studies and in cell-free assay systems for HMG-CoA studies.

• Product name

  Lovastatin (Mevinolin), HMG-CoA reductase inhibitor

• Description

  Potent HMG-CoA reductase inhibitor

• Alternative names

  • Mevinolin

• Biological description

  Potent, competitive HMG-CoA reductase inhibitor (K_i = 0.6 nM). Blood-brain barrier permeable. Inhibits in vivo and in vitro cholesterol biosynthesis. Also reduces α-synuclein levels in vitro and in vivo.

• Purity

  > 98%

• CAS Number

  75330-75-5

• Chemical structure

  

1. Invigorate the spleen and eliminate food, invigorate the blood and remove blood stasis;
2. Lowering blood lipids, lowering total cholesterol, reducing enzyme inhibitors, directly inhibiting hng-coa reductase, and blocking cholesterol synthesis;
3. Lovastatin can effectively reduce the serum cholesterol content of patients with mixed familial and non-familial hypercholesterolemia.

1. Food additives, coloring agents (meat products, juice, color wine, jam, beverage, candy, pastry, soy sauce, health vinegar, etc.;
2. Pharmaceutical coloring agents, functional health products;

3. Cosmetics category.