Buy 84605-18-5 High Purity Cycloastragenol 84605-18-5 Cycloastragenol powder

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Buy 84605-18-5 High Purity Cycloastragenol powder

Cycloastragenol, the aglycone derivative of astragaloside A (Item No. 16677), can be found in various species of Astragalus and is reported to activate telomerase. It has been shown to slow telomere loss, increase replicative capacity, and improve immune function in CD8⁺ T lymphocytes from HIV-1-infected patients.

Cycloastragenol is a molecule isolated from various species in the genus Astragalus that is purported to have telomerase activation activity. lt is used as a nutraceutical and seems to moderately increase the telomerase activity and proliferative capacity of both CD4 and CD8 T-cells. lt has anti-aging properties. lt stimulates the repair of DNA damage by activating telomerase, a nucleoprotein enzyme which catalyses synthesis and growth of telomeric DNA.

Cycloastragenol, a natural tetracyclic triterpenoid, was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties. IC50 value:Target:In vitro: In the study of Cycloastragenolon the treatment of degenerative diseases, the result showed that first-pass intestinal metabolism of cycloastragenol might occur upon passage through the intestinal epithelium. Cycloastragenol underwent extensive metabolism in rat and human liver microsomes with only 17.4% and 8.2%, respectively, of the starting amount of Cycloastragenol remaining after 30 min of incubation. The present study demonstrates that cycloastragenol stimulates telomerase activity and cell proliferation in human neonatal keratinocytes. In particular, cycloastragenol promotes scratch wound closure of human neonatal keratinocyte monolayers in vitro. In vivo: Rats were treated with Cycloastragenol (40 mg·kg- 1·d- 1) for 7 days to induce hepatic microsomal enzyme. The result showed that compared with the control, cycloastragenol obviously activated CYP2E1, and remarkably inhibited CYP3A4.