65277-42-1 in stock Ketoconazole High quality Ketoconazole on hot selling

65277-42-1 in stock Ketoconazole High quality Ketoconazole on hot selling

Min.Order / FOB Price:Get Latest Price

1 Kilogram	FOB Price:USD 99.0000 -119.0000

1 Kilogram

FOB Price:USD 99.0000 -119.0000

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : D/A,D/P,T/T,Other

Keywords

65277-42-1 in stock Ketoconazole High quality Ketoconazole on hot selling

Quick Details

Appearance:white powder
Application:Health care grade,API,
PackAge:Bottle, Drum, Vacuum Packed, Plastic bag
ProductionCapacity:55|Metric Ton|Month
Storage:Sealed, dry and refrigerated
Transportation:By Express,Air,Sea

Superiority:

65277-42-1 in stock Ketoconazole High quality Ketoconazole on hot selling

Ketoconazole is a broad-spectrum triazole antifungal agent that has activity against C. albicans, C. krusei, C. tropicalis, C. glabrata, C. parapsilosis, C. neoformans, and A. fumigatus strains (IC₅₀s = 0.031-8 µg/ml).It inhibits the fungal cytochrome P450 (CYP) isoform CYP51, also known as lanosterol 14α-demethylase, which arrests ergosterol (Item No. 19850) biosynthesis at the fungal membrane. Ketoconazole also inhibits human CYP3A4 (IC₅₀ = 0.54 µM). Formulations containing ketoconazole have been used in the treatment of fungal infections.

Ketoconazole is an inhibitor of cytochrome P450c17. Enhances the formation of myelin basic protein-positive oligodendrocytes from oligodendrocyte progenitor cells in vitro and promotes remyelination in vivo. Also an antifungal agent. Brain penetrant.

Ketoconazole is an imidazole-containing small molecule inhibitor of cytochrome P-450-dependent steps in the biosynthesis of steroid hormones; also inhibits TXA Synthase (thromboxane synthetase) and 5-LO (5-lipoxygenase) activity. Ketoconazole exhibits antimetastatic, antineoplastic, and antipsoriatic activity. Inhibition of 5-LO (5-lipoxygenase) by Ketoconazole interrupts arachidonic acid (sc-200770)-derived leukotriene production, which was correlated to a suppression of leukotriene-mediated anaphylactic bronchoconstriction in guinea pigs. Ketoconazole is described as reducing platelet cellular levels of thromboxane A₂, suppressing thromboxane A₂-mediated increase of microvascular permeability in response to ischemia insults. Ketoconazole produces an antiandrogen effect through inhibition of adrenocorticoid biosynthesis, suppressing the adrenal secretion of androgens and attenuating cortisol response. Ketoconazole is an inhibitor of CYP17A1, CYP3A4 and CYP3A5.

Details:

Raw material 99% Ketoconazole powder price for soap cas 65277-42-1

Product information

Ketoconazole is a synthetic antifungal used to prevent and treat fungal skin infections, especially in immunocompromised patients such as those with AIDS or those on chemotherapy. Ketoconazole is sold commercially as an anti-dandruff shampoo, topical cream, and oral.

Product Name	Ketoconazole
Apperance	White Powder
Cas.No.	65277-42-1
Test Method	HPLC

Product Function

1.Ketoconazole is usually prescribed for fungal infections of the skin and mucous membranes, such as athlete's foot, ringworm, candidiasis (yeast infection or thrush), jock itch, and tinea versicolor.
2.Topical ketoconazole is also used as a treatment for dandruff (seborrheic dermatitis of the scalp) and for seborrheic dermatitis on other areas of the body, perhaps acting in these conditions by suppressing levels of the fungus Malassezia furfur on the skin.

Product Application

1. Anti-Hair loss
Ketoconazole shampoo in conjunction with an oral 5α-reductase inhibitor has been used off label to treat and rogenic alopecia. The antifungal properties of ketoconazole reduce scalp microflora and consequently may reduce follicular inflammation that contributes to alopecia.Limited clinical studies suggest ketoconazole shampoo used either alone or in
combination with other treatments may be useful in reducing hair loss.
2.At least one study has been performed showing that ketoconazole may be useful in temporarily reducing erectile function in postoperative penile surgery patients.
3.Veterinary use
Ketoconazole is also sometimes prescribed by veterinarians for use on pets, often as unflavored tablets that may need to be cut to smaller size for correct dosage.