CasNo.50-02-2,50-02-2 Dexamethasone powder good supplier 50-02-2 Dexamethasone China,(50-02-2) Suppliers

100 Kilogram	FOB Price:USD 0.7500 -0.8500

Min.Order :100 Kilogram
Purity: 99%
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50-02-2 Dexamethasone powder good supplier 50-02-2 Dexamethasone China

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Appearance:White powder
Application:1. Dextromethorphan powder is used to treat a dry (nonproductive) cough caused by colds, flu or inhaled irritants. 2. The primary use of dextromethorphan hydrobromide is as an antitussive, or cough
PackAge:1kg with double plastic container inside/Aluminum foil bag outside. 25kg with double plastic container inside/Fiber drum outside.
ProductionCapacity:100000000|Kilogram|Year
Storage:Stored in a clean, cool, dry area; keep away from strong
Transportation:by express /air/sea

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Dexamethasone powder good supplier 50-02-2 Dexamethasone China

Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (K_d = 5 nM versus 17 nM, respectively).¹ Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results.

Dexamethasone is a synthetic glucocorticoid compound with potent anti-inflammatory activities. Dexamethasone binds more powerfully to the glucocorticoid receptor than cortisol dose. Usually, glucocorticoid receptors (GRs) bind to heat shock protein 90 (HSP90). For the receptors, dexamethasone binding promotes dissociation of the receptor from HSP90 and conversion of the receptor to the DNA (glucocorticoid responsive element, GRE)-binding state, resulting in inducing change in regulating mRNA expression that lead to anti-inflammatory reactions.

Details:

Dexamethasone is a glucocorticoid; anti-inflammatory. Reduces levels of activated NF-κB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Induces differentiation of human mesenchymal stem cells (MSCs). Also used in the generation of liver organoids. Induces autophagy in acute lymphoblastic leukemia (ALL) cell lines. Acts as viral transduction enhancer by promoting intracellular shuttling of HIV-1 pre-integration complex to the nucleus. Additionally Dexamethasone pretreatment in vivo suppresses adaptive immune response to recombinant adenoviral gene transfer vectors.

Anti-inflammatory glucocorticoidDexamethasone is used to treat inflammatory and autoimmune conditions such as rheumatoid arthritis and bronchospasm. It is useful to study apoptosis, cell signaling pathways and gene expression. It is associated with marbofloxacin and clotrimazole and finds application in veterinary medicine to treat difficult ear infections in dogs. It is also used to treat horses with swelling of of distal limbs and general bruising in combination with trichlormethiazide. It is also an anti-inflammatory glucocorticoid.

Alternate Name	9α-Fluoro-16α-methylprednisolone, Prednisolone F, (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione
Appearance	Liquid
Formulation	DMSO (10 mM)
CAS #	50-02-2
Molecular Formula	C??H??FO?
Molecular Weight	392.46
Purity	>99% by TLC
SMILES	CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
InChi	InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChi Key	UREBDLICKHMUKA-CXSFZGCWSA-N
PubChem CID	5743
MDL Number	MFCD00064136
Handling	Protect from light and moisture
Storage Conditions	-20°C
Shipping Conditions	Gel Pack