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Competitive price Gastrodin Gastrodia Elata Extract Gastrodin in bulk supply 62499-27-8 in stock
Competitive price Gastrodin Gastrodia Elata Extract Gastrodin in bulk supply 62499-27-8 in stock
Gastrodin is a phenolic glycoside that has been found in Gastrodia and has diverse biological activities. It reduces cell death of rat hippocampal neurons and BV-2 mouse microglia induced by amyloid-β (1-42) (Aβ42; Item No. 20574) and improves learning and memory in various transgenic mouse models of Alzheimer's disease. It reduces motor deficits and loss of dopaminergic neurons in a rat model of Parkinson's disease induced by 6-OHDA (Item No. 25330). Gastrodin (50-200 mg/kg) reduces seizure duration and intensity in a rat model of pentylenetetrazole-kindling chronic epileptic seizures. In a mouse model of valproic acid-induced autistic-like phenotypes, gastrodin (100 mg/kg) increases social interaction and decreases marble burying and grooming behaviors, as well as restores inhibitory synaptic transmission and GAT1 and α5 subunit-containing GABAA expression in the basolateral amygdala. Gastrodin increases ultimate breaking force and bone stiffness, measures of biomechanical strength, in a rat model of osteoporosis induced by dexamethasone (Item No. 11015). It also inhibits ethanol-induced hepatocellular apoptosis and restores liver function in a rat model of alcoholic liver disease.
Catalogue Number | G245550 |
Chemical Name | Gastrodin |
Synonyms | 4-(β-D-Glucopyranosyl)-benzylalcohol; 4-(β-D-Glucopyranosyloxy)benzyl Alcohol; 4-Hydroxybenzyl Alcohol 4-O-β-D-Glucopyranoside |
CAS Number | 62499-27-8 |
Molecular Formula | C??H??O? |
Molecular Weight | 286.28 |
Category | Standards; Carbohydrates and Oligosaccharides; |
Applications | Gastrodin up regulates heme oxygenase-1 expression through activation of p38 MAPK/Nrf2 signaling pathway thus protecting the SH-SY5Y cells from MPP+-induced oxidative cell death. |
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