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Cholecalciferol lowest price Vitamin d3 good supplier 67-97-0

Vitamin D3 is used as an essential mediator of intestinal calcium absorption and bone calcium metabolism. It is also used as a therapeutic vitamin. Further, it is used as a nutritional supplement and to fortify foods. In addition to this, it is used as pharmaceutical drug and used in the treatment of respiratory diseases involving chronic inflammation such as asthma.

Cholecalciferol is a naturally occuring form of vitamin D. Reported that upon metabolic activation, Cholecalciferol induces cell differentiation and prevents proliferation of cancer cells. Cholecalciferol is an activator of VDR.

Cholecalciferol acts as a hormone precursor since it requires two stages of metabolism: first to 25-hydroxycholecalciferol; then to 1α, 25-dihydroxycholecalciferol. One unit (U.S.P. or international) is defined as the activity of 0.025 μg of vitamin D3 contained in the USP vitamin D reference standard.

Cholecalciferol is sourced either through the diet or exposing skin to ultraviolet rays. Oral administration of vitamin D₃ is readily absorbed and is stored in adipose tissue.

Cholecalciferol (Vitamin D₃) is known for the maintenance of normal skeleton architecture and mineral homeostasis. Vitamin D₃ is synthesized from 7-dehydrocholesterol [CAS: 434-16-2] in the skin under the influence of UV light, or it is obtained from food, especially fatty fish. The transformation (hydroxylation) of vitamin D₃ is catalyzed by enzymes in the liver and the kidney to produce calcitriol [C3078] (other name: 1α,25-dihydroxyvitamin D₃), the active form of vitamin D₃. Calcitriol is active in the regulation of the absorption of calcium from the gastrointestinal tract.