Hot sale RU-58841 in bulk supply 154992-24-2 RU58841 in China

Hot sale RU-58841 in bulk supply 154992-24-2 RU58841 in China

Min.Order / FOB Price:Get Latest Price

100 Gram	FOB Price:USD 4.5000 -11.8000

100 Gram

FOB Price:USD 4.5000 -11.8000

Min.Order :100 Gram
Purity: 99%
Payment Terms : D/A,D/P,T/T,,MoneyGram,Other

Keywords

Hot sale RU-58841 in bulk supply 154992-24-2 RU58841 in China

Quick Details

Appearance:white powder
Application:Health care grade,API,
PackAge:Bottle, Drum, Vacuum Packed, Plastic bag
ProductionCapacity:55|Metric Ton|Month
Storage:Sealed, dry and refrigerated
Transportation:By Express,Air,Sea

Superiority:

Hot sale RU-58841 in bulk supply 154992-24-2 RU58841 in China

RU-58841 is a non-steroidal antiandrogen that binds to the androgen receptor (K_d = 1.8, 1.1, 5.6, 1.3, and 1.4 nM for human, rat, mouse, hamster prostate, and hamster flank organ receptors, respectively). In vivo, topical administration of RU-58841 (1-100 μg per animal) reduces size of the flank organ without affecting sex organs in a dose-dependent manner in hamsters. It has no effect on sex organ weight in intact rats when administered percutaneously, subcutaneously, or orally at doses up to 1 mg per animal. RU-58841 (5% v/v) also induces hair regrowth in the bald frontal scalps of postpubertal stumptailed macaques, a model for male pattern baldness

RU 58841 is a new non-steroidal antiandrogen which has potential for use in treating androgen-dependent skin disorders such as acne, hirsutism and androgen-dependent alopecia.

RU-58841 is a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism. The potent localized inhibition of sebaceous glands by RU 58841 demonstrates the excellent potential of this compound as a topical drug for the treatment of acne and other androgen-mediated disorders.

Details:

Alternate Name	RU58841 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
Appearance	Crystalline solid
CAS #	154992-24-2
Molecular Formula	C??H??F?N?O?
Molecular Weight	369.34
Purity	≥98% by HPLC
Solubility	>25 mg/ml (DMSO)
SMILES	CC1(C(=O)N(C(=O)N1CCCCO)C2=CC(=C(C=C2)C#N)C(F)(F)F)C
InChi	InChI=1S/C17H18F3N3O3/c1-16(2)14(25)23(15(26)22(16)7-3-4-8-24)12-6-5-11(10-21)13(9-12)17(18,19)20/h5-6,9,24H,3-4,7-8H2,1-2H3
InChi Key	ARBYGDBJECGMGA-UHFFFAOYSA-N
PubChem CID	132981
Handling	Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions	-20°C
Shipping Conditions	Gel Pack
USAGE	For Research Use Only! Not For Use in Humans.