2447-54-3 Good Supplier In China High Purity sanguinarine 2447-54-3 macleaya cordata extract sanguinarine

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Good Supplier In China High Purity sanguinarine 2447-54-3  macleaya cordata extract sanguinarine 

Sanguinarine is a naturally isolated benzophenanthridine alkaloid that exhibits a wide variety of beneficial properties, including chemotherapeutic, anti-inflammatory, and antibacterial activities. In breast cancer cells, sanguinarine increases levels of tissue inhibitor of metalloproteinase 1 and 2 (TIMP1 and TIMP2) and heme-oxygenase 1 (HO-1), decreases expression of matrix metalloproteinases (MMPs), prostaglandin E2 (PGE2), and COX-2, and inhibits the phosphorylation of Akt/ERK as well as the activation of NF-?B. Sanguinarine also inhibits VEGF release and increases levels of ROS, inducing apoptosis and inhibiting growth of cancer cells. In animal models of colitis, this compound decreases expression of IL-6, NF-?B, and TNF-?, resulting in decreases in weight loss, disease activity, and mortality. Sanguinarine increases oxidative stress and induces DNA damage in species of Microcystis, a cyanobacterium, inhibiting cell division. In species of Bacillus, this compound decreases bacterial membrane potential. Sanguinarine may also inhibit tubulin polymerization, allosterically activate AMPK, and inhibit amino acid carboxylase.

Sanguinarine possesses anticancer, antimicrobial, anti-inflammatory, and antioxidant properties, it has therapeutic potential in preventing the neurodegenerative diseases, it may be used to develop a potential therapeutic drug for treating cardiac remodeling and heart failure and shows protective effects on teeth and alveolar bone health. Sanguinarine can inhibit osteoclast formation and bone resorption via suppressing RANKL-induced activation of NF-κB and ERK signaling pathways, and can protect against cardiac hypertrophy and fibrosis via inhibiting NF-κB activation.