6902-77-8 in stock ...

6902-77-8 in stock lowest price Geniposide Supply Genipin
6902-77-8 in stock lowest price Geniposide Supply Genipin
6902-77-8 in stock lowest price Geniposide Supply Genipin
6902-77-8 in stock lowest price Geniposide Supply Genipin
6902-77-8 in stock lowest price Geniposide Supply Genipin

6902-77-8 in stock lowest price Geniposide Supply Genipin

Min.Order / FOB Price:Get Latest Price

1 Kilogram

FOB Price:USD 12.0000 -18.0000

  • Min.Order :1 Kilogram
  • Purity: 99%
  • Payment Terms : L/C,D/A,D/P,T/T,Other

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6902-77-8 in stock lowest price Geniposide Supply Genipin

Quick Details

  • Appearance:White Powder
  • Application:Used for Anti-cancer, protect the liver product.
  • PackAge:1kg with double plastic container inside/Aluminum foil bag outside. 25kg with double plastic container inside/Fiber drum outside.
  • ProductionCapacity:10|Metric Ton|Month
  • Storage:Cool Dry Place
  • Transportation:Fedex,TNT,DHL,Air transportion,sea transportion

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6902-77-8 in stock lowest price Geniposide Supply Genipin

Genipin is a compound isolated from gardenia fruits. Genipin is a water-soluble bifunctional crosslinking reagent with low cytotoxicity. Genipin is used as a good cross-linker for proteins, collagen, gelatin, and chitosan cross-linking. In addition, genipin can be used as a regulating agent for drug delivery, as an anti-inflammatory agent, and as the raw material for gardenia blue pigment preparation.

Genipin, a compound isolated from Gardenis jasminoides Ellis fruits, is a cell-permeable inhibitor of UCP2 activity. Genipin also exhibits anti-inflammatory and anti-angiogenic properties by inducing apoptosis in FaO rat hepatoma cells and human hepatocarcinoma Hep3B cells.

Uncoupling protein 2 (UCP2) is a mitochondrial carrier protein that is expressed in pancreatic islets and has been shown to negatively regulate glucose-stimulated insulin secretion. High levels of UCP2 expression can disrupt pancreatic β cell function and downregulate insulin secretion thereby contributing to the development of type 2 diabetes. Genipin, a compound isolated from Gardenis jasminoides Ellis fruits, was originally identified as a protein cross-linking agent. Genipin is a cell-permeable inhibitor of UCP2 activity.Genipin, at 5 µM, increases glucose-stimulated insulin secretion in isolated pancreatic islets chronically exposed to high levels of glucose. Genipin also exhibits anti-inflammatory and anti-angiogenic properties by inducing apoptosis in FaO rat hepatoma cells and human hepatocarcinoma Hep3B cells.

Details:

Genipin is a compound isolated from Gardenis jasminoides Ellis fruits which acts as a cell permeable inhibitor of uncoupling protein 2 (UCP2). Genipin increases glucose-stimulated insulin secretion, mitochondrial membrane potential and ATP levels in pancreatic island cells. Genipin has been shown to induce apoptosis and is a protein cross-linking agent. Genipin, at 5 μM, increases glucose-stimulated insulin secretion in isolated pancreatic islets chronically exposed to high levels of glucose. Genipin also exhibits anti-inflammatory and anti-angiogenic properties by inducing apoptosis in FaO rat hepatoma cells and human hepatocarcinoma Hep3B cells.

Catalogue number: PA PHY 004152
Chemical name: GENIPIN

CAS Number:

6902-77-8

Category: NA
Synonyms:

(+)-Genipin; 1,4aα,5,7aα-Tetrahydro-1-hydroxy-7-(hydroxymethyl)-cyclopenta[c]pyran-4-carboxylic Acid; [1R-(1α,4aα,7aα)]-1,4a,5,7a-Tetrahydro-1-hydroxy-7-(hydroxymethyl)-cyclopenta[c]pyran-4-carboxylic Acid Methyl Ester

Molecular form: C11H14O5
Appearance: NA
Mol. Weight: 226.23
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: Genipin is an inhibitor of uncoupling protein 2 (UCP2).
BTM: NA

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