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Ronidazole is an antiprotozoal agent.Target: AntiparasiticRonidazole is an antiprotozoal agent used in veterinary medicine. It may also have use for the treatment of Tritrichomonas foetus infection in cats. Ronidazole kills T foetus at concentrations > 0.1 μg/mL in vitro. Ronidazole (30 or 50 mg/kg) cures T foetus infection for follow-up durations of 21 to 30 weeks after treatment in 10/10 cats

Ronidazole is a carbamate ester with antiprotozoal and antibiotic activities. It is active against a panel of T. foetus isolates with minimum lethal concentrations (MLCs) ranging from 0.625 to 1.25 µg/ml. It is also active against C. difficile bacteria (MIC₉₀ = 0.125 µg/ml). Ronidazole (50 mg/kg) inhibits infection relapse in a cat model of experimental T. foetus infection. It also inhibits T. muris infection in mice when administered at a concentration of 400 mg/L in drinking water. Ronidazole (10 mg/kg) increases survival in a mouse model of C. difficile infection. Formulations containing ronidazole have been used in the treatment of T. foetus infection in cats.

 Ronidazole CAS 7681-76-7 is a carbamate ester that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by methyl and (carbamoyloxy)methyl groups, respectively. An antiprotozoal agent, it is used in veterinary medicine for the treatment of histomoniasis and swine dysentery. It has a role as an antiprotozoal drug and an antiparasitic agent.