Minoxidil for sale factory 38304-91-5 Minoxidil price

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Minoxidil for sale factory 38304-91-5 Minoxidil price

Minoxidil is an antihypertensive vasodilator medication also claiming to slow or stop hair loss and promote hair regrowth. It is available over the counter for treatment of androgenic alopecia, among other baldness treatments, but measurable changes, if experienced, disappear within months after discontinuation of treatment.
Minoxidil was first sold as a drug for high blood pressure and was noted to have the interesting side-effect of increased body hair-growth, or in some cases, significant hair loss. Treatments for baldness and hair loss usually include a 5% concentration solution that is designed for men, whereas the 2% concentration solutions are designed for women.

Minoxidil is an antihypertensive vasodilator agent and hair growth promoter that is metabolized by sulfation to the active compound, minoxidil sulfate [CAS: 83701-22-8]. The mode of action of the effects are still not completely understood, but the most plausible explanation is that minoxidil sulfate acts as an opener of vascular smooth muscle ATP dependent K⁺ (K_ATP) channels. Additionally, transdermal minoxidil delivery systems have been developed to increase the skin permeability.

Minoxidil is a pyrimidine derivative that was originally developed as an anti-hypertensive agent and unexpectedly found to stimulate hair growth. Minoxidil directly affects arteriolar smooth muscle to decrease vascular resistance in part by opening ATP-sensitive potassium channels. It can activate cyclooxygenase 1 (AC₅₀ = 80 μM), which is expressed in the dermal papilla of hair follicles, increasing prostaglandin E₂ production in BALB/c 3T3 fibroblasts and human dermal papilla fibroblasts.