Bitter Sophora Root Extract 98% Matrine 519-02-8 low price 519-02-8 Matrine On Sale

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Bitter Sophora Root Extract 98% Matrine low price 519-02-8 Matrine  On Sale

Matrine is an alkaloid found in S. flavescens roots that has diverse biological activities. It inhibits LPS-induced splenocyte proliferation and release of IL-1 and IL-6 from mouse peritoneal macrophages in vitro. In mice, administration of matrine inhibits the development of LPS-induced hepatitis in a dose-dependent manner. Matrine reduces production of the hepatitis B surface antigen (HBsAG) and serum antigen (HBeAG) with IC₅₀ values of 0.75 and 3.35 mg/mL, respectively, in vitro and inhibits viral replication in a duck model of hepatitis B. In vitro, matrine inhibits angiotension II-induced hyperplastic growth of cardiac fibroblasts in a dose-dependent manner.Matrine also inhibits proliferation of melanoma, breast, and colon cancer cells with IC₅₀s ranging from 0.769-2.758 mg/ml.

Matrine is a biologically active alkaloid isolated from the root of the saphoro plant. It inhibits LPS-induced splenocyte proliferation and release of IL-1 and IL-6 from mouse peritoneal macrophages in vitro. Matrine has been studied for possible antiviral efficacy against hepatitis B and C, as well as impact against some skin diseases and forms of cancer.

Matrine (519-02-8) is a natural product found in the plant Sophora flavescens.  It has been found to possess myriad biological activities including a positive inotropic effect, reduced glucose intolerance and hepatic steatosis in a mouse model via activation of HSP72, various anti-cancer effects.  Matrine has also recently been shown to induce RIP3-dependent necroptosis in cholangiocarcinoma cells.