global Bitter Almond Extract Amygdalin factory 29883-15-6 Amygdalin Good Supplier In China

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global Bitter Almond Extract Amygdalin  factory 29883-15-6 Amygdalin  Good Supplier In China

Amygdalin is a glycoside initially isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds. The active ingredient of amygdalin is a naturally occurring cyanide, which is a human metabolite and can only play a role in cancer cells.

Amygdalin is a cyanogenic glucoside isolated from almonds and seeds of other plants of the family Rosaceae. It displays anticancer and anti-inflammatory properties. It induces apoptosis as a result of increased expression of Bax protein and caspase-3 and reduced expression of antiapoptotic BcL-2 protein. Amygdalin can serve as a chemopreventive agent to prevent or alleviate progression of breast cancer, especially TNBC.

Amygdalin is a β-cyano-glycoside in the bitter almond that is bound to cyano (CN), which releases free cyano groups after eating the bitter almond, so that the food is poisoned. Amygdalin is a product of the metabolism of phenylalanine in the bitter almond. Amygdalin has β-glucosidase and amygdalinase (oxynitrilase): the former catalyzed amygdalin into two molecules of glucose and one molecule of amygdalenone through hydrolysis; the later catalyzes mandelonitrile into almond nitrile cyanide (HCN) and benzaldehyde through hydrolysis. Amygdalin exists in seeds, such as almonds.
Many plant root cells contain glycosides, with no toxic effect when in sugar type. Glycosides hydrolysis produce toxic substances leading to cell death. Mandelic glycosides contained in peach root is a glycoside. Amylose hydrolysis produce two kinds of plant toxins-hydrogen cyanide and benzaldehyde. Peeling root lesion formation and necrosis occurred in the vicinity of the stabbed nematode but not in contact zone; in addition, in vitro tests have proved that the pratylenchus penetrans can make amygdalin hydrolysis.