Pentostatin

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0 Metric Ton	Negotiable

0 Metric Ton

Negotiable

Min.Order :0 Metric Ton
Purity: 95%+
Payment Terms : T/T

Keywords

Pentostatin 53910-25-1 Pentostatin, in stock

Quick Details

Appearance:White to off-white powder
Application:Antitumor Adenosine deaminase inhibitor
PackAge:As per request
ProductionCapacity:|Metric Ton|Day
Storage:Store in a tight container at -20℃.
Transportation:by air or by sea

Superiority:

Product in stock

Short lead time

Cost competitiveness

Details:

Pentostatin is a potent transition state inhibitor of adenosine deaminase (ADA), the greatest activity of which is found in cells of the lymphoid system. T-cells have higher ADA activity than B-cells, and T-cell malignancies have higher activity than B-cell malignancies. The cytotoxicity that results from prevention of catabolism of adenosine or deoxyadenosine is thought to be due to elevated intracellular levels of dATP, which can block DNA synthesis through inhibition of ribonucleotide reductase. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).

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