Hot Sale 171596-29-5 supplier 171596-29-5 good producer Tadalafil

Min.Order / FOB Price:Get Latest Price

100 Gram	FOB Price: USD 1.0000

100 Gram

FOB Price: USD 1.0000

Min.Order :100 Gram
Purity: 99%
Payment Terms : T/T,

Keywords

Hot Sale 171596-29-5 supplier 171596-29-5 good producer Tadalafil

Quick Details

Appearance:white powder
Application: Male Sex Hormones
PackAge:10G/pack,100g/pack,1kg/pack (aluminium foil bag)
ProductionCapacity:10000|Kilogram|Year
Storage:Storage in a dry, ventilated place under normal temperature
Transportation:by EMS,FEDEX,UPS

Superiority:

Hot Sale 171596-29-5 supplier 171596-29-5 good producer Tadalafil

Tadalafil is a potent and highly selective PDE5 inhibitor (IC₅₀ = 5 nM). Exhibits > 2000-fold selectivity for PDE5 over PDEs 1,2,3 and 4 and 1000-fold selectivity over PDE6. Reduces blood pressure in hypertensive rats. Also delays tumor growth in a mouse model via inhibition of MDSC-mediated immunosuppression. Orally bioavailable.

Tadalafil (market name “Cialis” or “Adcirca”) is a kind of PDE5 inhibitor used for the treatment of erectile dysfunction, benign prostatic hypertrophy and pulmonary arterial hypertension. The effect of Tadalafil is relaxing the blood vessels muscles and increasing the blood flow into the corpus cavernosum. The mechanism of action of tadalafil is through inhibiting the activity of the cGMP specific phosphodiesterase type 5 (PDE5). PDE5 degrades cGMP in the corpus cavernosum located around the penis. Therefore, tadalafi leads to the increased concentration of cGMP which further causes the smooth muscle relaxation and increased blood flow into the corpus cavernosum. Some clinical studies also implied that tadalafil could improve endothelia function in men with increased cardiovascular risk and lower the urinary tract symptoms secondary to benign prostatic hyperplasia.

Details:

Catalogue Number	T004500
Chemical Name	Tadalafil
Synonyms	(6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione; Cialis; GF 196960; IC 351; ICOS 351; Tildenafil; UK 336017;
CAS Number	171596-29-5
Molecular Formula	C??H??N?O?
Appearance	White to Off-White Solid
Melting Point	>193°C (dec.)
Molecular Weight	389.40
Storage	Hygroscopic, -20?C Freezer, Under Inert Atmosphere
Solubility	Chloroform (Slightly), DMSO (Slightly)
Stability	Unstable in Methanol
Category	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications	Tadalafil is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.