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88495-63-0 low price 88495-63-0 factory sells Artesunate Good Supplier In China
88495-63-0 low price factory sells Artesunate Good Supplier In China
Artesunate is a derivative of artemisinin that is active against P. falciparum in vitro (IC50 = 1.28 nM). It is an iron(II) oxide-reactive endoperoxide that generates reactive oxygen species (ROS) upon cleavage of its endoperoxide bridge. Artesunate inhibits proliferation of germinal center B cells in vitro and prevents development of arthritis via inhibition of germinal center formation and autoantibody production in the K/BxN mouse model of rheumatoid arthritis. It also inhibits alveolitis and pulmonary fibrosis induced by bleomycin in rats.
Artesunate is a suppresses ROS-induced activation of the NLRP3 inflammasome. Arrests cell cycle in the G2/M phase and sensitizes human renal cell carcinoma (RCC) cell lines to sorafenib in vitro. Antimalarial.
Artesunate
C19H28O8
384.43
88495-63-0
INP/Enterprise Standard
Suitable for all kinds of cerebral malaria and severe malaria rescue
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