good producer 25316...

good producer 25316-40-9 Hot Sale 25316-40-9 Doxorubicin hydrochloride in stock
good producer 25316-40-9 Hot Sale 25316-40-9 Doxorubicin hydrochloride in stock

good producer 25316-40-9 Hot Sale 25316-40-9 Doxorubicin hydrochloride in stock

Min.Order / FOB Price:Get Latest Price

10 Gram

FOB Price: USD 10.0000

  • Min.Order :10 Gram
  • Purity: 99%
  • Payment Terms : T/T,

Keywords

good producer 25316-40-9 Hot Sale 25316-40-9 Doxorubicin hydrochloride in stock

Quick Details

  • Appearance:white powder
  • Application:Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological proper
  • PackAge:10g/pack,100g/pack,1kg/pack
  • ProductionCapacity:10000|Gram|Month
  • Storage:Store in dry、dark、ventilated place.
  • Transportation:BY EMS

Superiority:

good producer 25316-40-9 Hot Sale Doxorubicin hydrochloride in stock

Doxorubicin hydrochloride is a DNA intercalator and powerful cytotoxic agent. Once Doxorubicin hydrochloride associates with the DNA groove, a covalent linkage forms between a DNA base and the pendant sugar of the small molecule. The intercalation into DNA blocks the replication of DNA by blocking Topo II (Topoisomerase II). This general mechanism gives Doxorubicin hydrochloride efficacy in a wide range of different cell types. Additionally, the expression of the oncogenes c-Myc and c-Jun is also down regulated by the chemical and a significant correlation was reported between the level of expression of these genes and the degree of cell growth inhibition conferred by Doxorubicin hydrochloride. Doxorubicin hydrochloride is an inhibitor of AMPK, TERT and POLR. Doxorubicin hydrochloride is also known as Hydroxydaunorubicin Hydrochloride, DOX, and (8S,10S)-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione, monohydrochloride.

Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.

 

Details:

Antitumor antibiotic agent that inhibits DNA topoisomerase II.Doxorubicin hydrochloride is used as an antineoplastic, antibiotic agent that inhibits DNA topoisomerase. It also inhibits nucleic acid synthesis and induces apoptosis. It posses fluorescent property, which enable it for the measurement of drug efflux pump activities and the role of subcellular organelles (golgi and lysosome) in the sequestration of drugs.

 

  • Product name

    Doxorubicin hydrochloride, Topoisomerase II inhibitor

  • Description

    Topoisomerase II inhibitor. Antibiotic with cytotoxic actions.

  • Alternative names

    • Adriamycin

  • Purity

    > 98%

  • CAS Number

    25316-40-9

  • Chemical structure

    Chemical Structure

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