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White or almost white powder.Somatotropin, a second-generation (methionine-free) human growth hormoneproduced by recombinant technology, was launched in the U.S.A. for the treatmentof growth failure in children due to chronic renal insufficiency before transplantationand for the long term treatment of short stature in children with growth failure due to alack of endogenous growth hormone secretion. The efficacy of somatotropin isreportedly comparable to the first biosynthetic growth h

Somatropin is a drug that has been approved by the U.S. Food and Drug Administration (FDA) for various uses, though it is mainly used to treat growth disorders in children and growth hormone deficiency in adults. Somatropin is FDA-approved to treat HIV-associated wasting or cachexia in people with HIV. Off-label use of somatropin may include treatment of HIV-associated lipodystrophy syndrome.

As an investigational HIV drug, somatropin belongs to a group of drugs called immune modulators. Immune modulators (also called immunomodulators) are substances that help to activate, boost, or restore normal immune function. Researchers are studying whether somatropin in combination with antiretroviral therapy (ART) can help reduce the latent HIV reservoir.

To learn about how investigational drugs are tested during clinical trials, read the HIVinfo What is an Investigational HIV Drug and HIV/AIDS Clinical Trials fact sheets.