Anastrozole Wholesa...

Anastrozole Wholesaler 120511-73-1 factory supply 120511-73-1 supplier
Anastrozole Wholesaler 120511-73-1 factory supply 120511-73-1 supplier
Anastrozole Wholesaler 120511-73-1 factory supply 120511-73-1 supplier
Anastrozole Wholesaler 120511-73-1 factory supply 120511-73-1 supplier
Anastrozole Wholesaler 120511-73-1 factory supply 120511-73-1 supplier

Anastrozole Wholesaler 120511-73-1 factory supply 120511-73-1 supplier

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Anastrozole Wholesaler 120511-73-1 factory supply 120511-73-1 supplier

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  • Appearance:White solid
  • Application:pharmaceutical intermediates
  • PackAge:1kg/Aluminum foil package, 25Kg/Drum
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Anastrozole Wholesaler 120511-73-1 factory supply 120511-73-1 supplier

Anastrozole is known to inhibit the CYP19 enzyme (aromatase, IC50 = 15 nM) that converts androgens to estrogens. Anastrozole has been seen to reversibly bind to the CYP19 enzyme through competitive inhibition.

Anastrozole, chemically known as 2,2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]bis(2-methylpropiononitrile) a derivative of benzotriazole with the CAS registry number 120511-73-1, is a non-steroidal, third-generation achiral triazole derivative marketed as ARIMIDEX® by AstraZeneca Pharmaceuticals LP1. It is one of the third-generation aromatase inhibitor which is a highly competitive and selective inhibitor of aromatase, thus blocking the conversion of testosterone into estradiol and androstenedione into estrone. Inhibition of the aromatase enzyme occurs particularly through competitive binding of aromatase to the hemegroup of cytochrome P450, decreasing estrogen biosynthesis in the peripheral tissues of the body and in the breast.

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Anastrozole has significant effects on breast cancer treatment and, therefore, it is currently used as first-line treatment in estrogen receptor (ER)-positive postmenopausal women, particularly to treat locally advanced or metastatic breast cancer. Furthermore, it is also indicated for early cancer treatment, tumor chemoprevention and postmenopausal women using tamoxifen, especially if the drug is used during a prolonged period of time and has been indicated in the disease’s recurrence, i.e., as another therapeutic endocrine option.

Catalogue Number A637425
Chemical Name Anastrozole
Synonyms α1,α1,α3,α3-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile; 2-[3-(2-Cyano-2-propyl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropiononitrile; Anastrazole; Anastrol; Arimidex; ICI-D 1033; ZD 1033
CAS Number 120511-73-1
Molecular Formula C??H??N?
Appearance White to Off-White Solid
Melting Point 81-82°C
Molecular Weight 293.37
Storage -20°C Freezer
Solubility Chloroform (Slightly), Methanol (Slightly)
Category Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications An aromatase inhibitor. Used as an antineoplastic.
  Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

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