Loperamide hydrochloride manufacturer 34552-83-5 in stock low price 34552-83-5
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Loperamide hydrochloride manufacturer 34552-83-5 in stock low price 34552-83-5
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- Appearance:White solid
- Application:pharmaceutical intermediates
- PackAge:1kg/Aluminum foil package, 25Kg/Drum
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Loperamide hydrochloride manufacturer 34552-83-5 in stock low price
Loperamide hydrochloride is a high affinity μ-opioid receptor agonist with peripheral selectivity (Ki values are 2, 48 and 1156 nM for μ-, δ- and κ-opioid receptors respectively). Antidiarrhoeal and antihyperalgesic agent. Also a Ca2+ channel blocker; at low micromolar concentrations it blocks broad spectrum neuronal HVA Ca2+ channels and at higher concentrations it reduces Ca2+ flux through NMDA receptor operated channels. Inhbits replication of MERS-CoV and SARS-CoV in vitro.
Loperamide is an opiate which potently and selectively activates μ opioid receptors (Ki = 0.16 nM) exclusively in the periphery. Loperamide is an opiate which potently and selectively activates μ opioid receptors (Ki = 0.16 nM) exclusively in the periphery.It is a much weaker agonist of the δ opioid receptor (Ki = 50 nM). Through its actions in the gut wall, loperamide has antidiarrheal action by increasing transit time and by altering intestinal transport of water and electrolytes.It also blocks voltage-
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Loperamide hydrochloride, an opioid agonist, reduces gastrointestinal motility in animals and human through activation of opioid receptors in the gastrointestinal tract. It cannot readily cross the blood-brain barrier, and does not appear to exert opiate activity in human. Loperamide is used as an antidiarrheal agent.
| Catalogue Number | L469450 |
| Chemical Name | Loperamide Hydrochloride |
| Synonyms | 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide Hydrochloride; Arret; Blox; Brek; Dissenten; Fortasec; Imodium; Imodium A-D; Imosec; Imossel; Lopemid; Lopemin; Loperazine; Loperyl; Lopodium; Maalox Antidiarrheal; NSC 696356; PJ 185; R 18553; Suprasec; Tebloc; |
| CAS Number | 34552-83-5 |
| Alternate CAS # | Free Base: 53179-11-6 |
| Molecular Formula | C??H??Cl?N?O? |
| Appearance | White Solid |
| Melting Point | 223-225?C |
| Molecular Weight | 513.50 |
| Storage | Refrigerator |
| Solubility | Acetone (Slightly, Heated), Methanol (Slightly), Water (Slightly) |
| Category | Standards; Pharmaceutical/API Drug Impurities/Metabolites; |
| Applications | Used as an antidiarrheal. |
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