Beta-Nicotinamide M...

Beta-Nicotinamide Mononucleotide（NMN） in bulk supply 1094-61-7 global trade Hot Sale 1094-61-7
Beta-Nicotinamide Mononucleotide（NMN） in bulk supply 1094-61-7 global trade Hot Sale 1094-61-7
Beta-Nicotinamide Mononucleotide（NMN） in bulk supply 1094-61-7 global trade Hot Sale 1094-61-7
Beta-Nicotinamide Mononucleotide（NMN） in bulk supply 1094-61-7 global trade Hot Sale 1094-61-7
Beta-Nicotinamide Mononucleotide（NMN） in bulk supply 1094-61-7 global trade Hot Sale 1094-61-7

Beta-Nicotinamide Mononucleotide（NMN） in bulk supply 1094-61-7 global trade Hot Sale 1094-61-7

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Beta-Nicotinamide Mononucleotide（NMN） in bulk supply 1094-61-7 global trade Hot Sale 1094-61-7

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  • Appearance:White solid
  • Application:pharmaceutical intermediates
  • PackAge:1kg/Aluminum foil package, 25Kg/Drum
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  • Storage:Normal temperature
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Beta-Nicotinamide Mononucleotide（NMN） in bulk supply 1094-61-7 global trade Hot Sale 1094-61-7

β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+; Item No. 16077). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate β-NMN, which is subsequently converted to NAD+ by β-NMN adenyltransferase.At 50-100 µM, β-NMN has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in a Nampt+/- mouse model of metabolic disease, demonstrating a role for Nampt in β cell function. Furthermore, at 500 mg/kg/day, it has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD+ levels.

β-Nicotinamide mononucleotide is a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.

Details:

3-Carbamoyl-1-beta-D-ribofuranosyl pyridinium hydroxide-5'phosphate, inner salt. A nucleotide in which the nitrogenous base, nicotinamide, is in beta-N-glycosidic linkage with the C-1 position of D-ribose. Synonyms: Nicotinamide Ribonucleotide; NMN.

Alternate Name β-NMN, β-Nicotinamide ribose monophosphate, NMN, Nicotinamide ribotide, Nicotinamide-1-ium-1-β-D-ribofuranoside 5′-phosphate
Appearance White lyophilzed solid
CAS # 1094-61-7
Molecular Formula C??H??N?O?P
Molecular Weight 334.22
Purity ≥98% by HPLC
Solubility H?O (50 mg/ml)
SMILES C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)[O-])O)O)C(=O)N
InChi InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/m1/s1
InChi Key DAYLJWODMCOQEW-TURQNECASA-N
PubChem CID 14180
MDL Number MFCD00038748
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

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