107868-30-4 for sale Exemestane Supply

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107868-30-4 for sale  Exemestane Supply

Exemestane is a steroidal aromatase inactivator. Its structure is similar to androstenedione, the natural substrate of aromatase. It is a pseudo-substrate of aromatase. Since the estrogen of postmenopausal women is mainly produced by the conversion of androgens (produced by the adrenal cortex) under the action of aromatase in peripheral tissues, this product is inactivated by irreversibly binding to the active site of aromatase, which is obvious Reduce the level of estrogen in the blood circulation of menopausal women. This product has no significant effect on the biosynthesis of adrenal corticosteroids. Even when the concentration is higher than 600 times the concentration that inhibits the effect of aromatase, it has no significant effect on other enzymes in the corticosteroid production pathway. This product is quickly absorbed orally, and its absorption is affected by food. The oral bioavailability is 42%. The drug absorption rate of postmenopausal women is higher than that of healthy subjects. Patients reach the peak plasma concentration 2 to 4 hours after oral administration of this product. The peak time is 1.2 hours on average, which is shorter than that of healthy subjects (2.9 hours). It mainly binds to α1-acid glycoprotein and protein, with a total protein binding rate of 90%. It is mainly injected through the liver, the metabolite is inactive 17-hydroexemestane, and the elimination half-life is 24 hours. 
Mainly excreted in urine or feces, each accounting for 42% of the dose.