compectitive price 99-92-3 4-Aminoacetophenone High quality

Details:

production method

(1) Reduction by p-nitroacetophenone: Put stannous chloride and concentrated hydrochloric acid into the reaction tank, cool, and add p-nitroacetophenone with stirring. When the temperature is naturally raised to 90°C, it is rapidly cooled to 85°C, then cooled to room temperature, stirred for 1 hour, filtered, and the filter cake is added with excess sodium hydroxide solution to decompose the complex. After filtration, the crude product of p-aminoacetophenone can be obtained. When dilute ethanol is used, it can be recrystallized to obtain a refined product with a melting point of 105-106°C. The yield is 61%. The reduction reaction can also be carried out by replacing stannous chloride with iron powder and sodium chloride.

(2) Acetaminoacetophenone is prepared from acetanilide and acetic anhydride, and then hydrolyzed and neutralized. Acetic anhydride, acetophenone, and anhydrous zinc chloride are mixed and kept boiled for 5h, cool slightly, pour in concentrated hydrochloric acid, reflux and hydrolyze for 5h, put it to room temperature, add 25% sodium hydroxide to adjust the pH to 7-8, and add steam Drive off the aniline, filter with decolorizing charcoal, concentrate under reduced pressure, and cool to obtain orange-yellow crystals. Drain to a crude product. Recrystallize and purify with water again.

4- amino acetophenone uses   Purpose 1

Used as raw material for medicine asthma cough

【 Purpose 2 】Used as a sensitive reagent for determination of palladium and determination of vitamin B1

【 Purpose 3 】An intermediate of the medicine asthma cough. Also used to determine palladium and vitamin B1.

【 Purpose 4 】Palladium and vitamin B1 were measured. A photometric reagent for cerium. Sulfanilamide analog colorimetric determination.