Amitriptyline hydrochloride

Superiority:

Amitriptyline hydrochloride Basic information
Overview Pharmacokinetics Indication Mode of action Adverse reactions Precautions Reference
Product Name:    Amitriptyline hydrochloride
Synonyms:    Amiplin;Normaln;Amitriptyline Hydrochloride (200 mg);Methanol (test Amitriptyline HCl, 1.0 mg/mL as free base);3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride;Amitriptyline hydrochloride 98+%;Amitriptyline hydrochloride solution ;3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride
CAS:    549-18-8
MF:    C20H24ClN
MW:    313.86
EINECS:    208-964-6

Mol File:    549-18-8.mol
Amitriptyline hydrochloride Structure
Amitriptyline hydrochloride Chemical Properties
Melting point     196-197°C
Fp     11 °C
storage temp.     2-8°C
solubility     H2O: soluble
pka    9.4(at 25℃)
form     powder
color     white to off-white
PH    4.5～6.0 (10g/l, 25℃)
Water Solubility     almost transparency
Merck     14,487
CAS DataBase Reference    549-18-8(CAS DataBase Reference)
EPA Substance Registry System    Amitriptyline hydrochloride (549-18-8)
Safety Information
Hazard Codes     T,F,N,Xn
Risk Statements     23/24/25-36/37/38-42/43-63-39/23/24/25-11-50/53-36-22
Safety Statements     22-26-36/37/39-45-36/37-16-61-60-7
RIDADR     UN 2811 6.1/PG 3
WGK Germany     3
RTECS     HO9450000
TSCA     Yes
HazardClass     6.1(b)
PackingGroup     III
HS Code     29214990
Hazardous Substances Data    549-18-8(Hazardous Substances Data)
Toxicity    LD50 in mice, rats (mg/kg): 350, 380 orally; 65, 75 i.p. (Tobe)