62-44-2 in stock Hot Sale 62-44-2 Phenacetin Good Supplier In China

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62-44-2 in stock Hot Sale 62-44-2 Phenacetin Good Supplier In China

The antipyretic and analgesic effect of phenacetin is similar to "acetylsalicylic acid". It is mainly used as an antipyretic and analgesic. The effect is slow and long lasting. It has good curative effect on the treatment of headache, neuralgia, arthralgia and fever. , But its anti-rheumatic and anti-inflammatory effects are weak. 
Excessive doses can lead to methemoglobinemia and cause hypoxia in the body. Long-term medication can damage the kidneys and even cause nipple necrosis. It should be used with caution. Due to its toxic side effects and the rapid development of other similar drugs, the drug has ceased to be used alone, but used as a compound preparation for raw materials and other drugs. It is often combined with aspirin and caffeine to form compound aspirin. Its composition is 0.162 g phenacetin, 0.227 g aspirin, and 0.035 g caffeine. It is less toxic and is used to treat colds and flu. If a small amount of chlorpheniramine is added to the above-mentioned drugs, it can also be made into chlorpheniramine-sensitive cold tablets, which can be used to treat colds, headaches, neuralgia, rheumatism, etc. Phenacetin itself has no antipyretic and analgesic effect. In the body, paracetamol, namely paracetamol, is metabolized and decomposed into the body to exert its antipyretic and analgesic effect. 
It also decomposes p-aminophenethyl ether, which not only has no antipyretic and analgesic effect, but also is the main factor of phenacetin's side effects. China began to produce phenacetin in 1954, which was obtained by etherification of nitrochlorobenzene and ethanol to obtain p-nitrophenyl ethyl ether, which was then reduced to p-aminophenyl ethyl ether and then acetylated with acetic acid.