CasNo.155213-67-5,factory supply GMP,DMF Lopinavir,(155213-67-5) Suppliers

1 Kilogram	Negotiable

Min.Order :1 Kilogram
Purity: USP/EP/BP
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Keywords

Lopinavir Anti-AIDS 155213-67-5

Quick Details

Appearance:White crystallization
Application:Anti- Virus response
PackAge:1kg/tin
ProductionCapacity:1|Metric Ton|Day
Storage:
Transportation:AIR SEA TRAIN

Superiority:

We are very compeitive on Lopinavir.Our mfr is GMP certified for this item with DMF document.

Product Name:	Lopinavir
Synonyms:	LOPINAVIR;(2s)-n-[(2r,4s,5s)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenyl-hexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide;(aS)-N-[(1S,3S,4S)-4-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-(1-methylethyl)-2-oxo-1(2H)-Pyrimidineacetamide;A 157378.0;ABT 378;Aluviran;Koletr;134368
CAS:	192725-17-0
MF:	C37H48N4O5
MW:	628.81
EINECS:	200-001-8
Product Categories:	Pharmaceutical;Other APIs;Anti-viral Compounds;Anti-virals;Intermediates & Fine Chemicals;Chiral Reagents;Non-nucleoside Reverse Transcriptase;Pharmaceuticals;Pepetides;ProteaseInhibitors;API;peptides;ABT-378
Mol File:	192725-17-0.mol

Details:

Lopinavir Chemical Properties

Melting point	255.2-260.6 °F (124—127°C)
Boiling point	924.1±65.0 °C(Predicted)
density	1.163±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble20mg/mL, clear
form	powder
pka	13.89±0.46(Predicted)
color	white to beige
optical activity	[α]/D -20 to -27°, c = 0.4 in methanol
Stability:	Hygroscopic
CAS DataBase Reference	192725-17-0(CAS DataBase Reference)

Safety Information

RIDADR	3077
HS Code	29335990
Hazardous Substances Data	192725-17-0(Hazardous Substances Data)

MSDS Information

Lopinavir Usage And Synthesis

Description

Lopinavir, the sixth HIV protease inhibitor in the “navir” class, was launched in coformulation with ritonavir, another HIV protease inhibitor already marketed (Abbott, 1996); this original formulation was introduced as Kaletra for use in combination with either nucleoside or non-nucleoside reverse transcriptase inhibitors for the treatment of AIDS in adults and children. Lopinavir is a peptidomimetic compound with a structural core identical to that of ritonavir, on which terminal groups, particularly a modified valine, were introduced by peptide coupling procedures. Lopinavir is a potent competitive inhibitor of HIV-I protease exhibiting high potential against ritonavir-resistant mutations. In several animal species, pharmacokinetic studies with the lopinavirlritonavir association showed that the modest properties of lopinavir were significantly improved in presence of ritonavir, in terms of Cmax and duration of action. Ritonavir inhibits the P450 isoenzyme CYP3A4 and the human liver microsomal metabolism of lopinavir, so strongly amplifying plasma levels of this latter component. In AIDS patients, the plasma HIV RNA level was considerably reduced and the CD4+ T-cell counts increased after administration of lopinavir combined with relatively small doses of ritonavir. Kaletra is intended to be used jointly with other antiretroviral agents.

Chemical Properties

White Crystalline Solid