Veterinary Drug Doramectin Powder CAS 117704-25-3 99% Doramectin

Details:

Doramectin:

 Avermectin A1a, 25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)-; (5'S,6S,6'R,11R,13S,15S,17aR,20R,20aR,20bS)-6'-cyclohexyl-20,20b-dihydroxy-5',6,8,19-tetramethyl-17-oxo-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl (4xi)-2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-threo-hexopyranoside

Specification:

Items	Specification	Result
Appearance	White powder	White powder
Identification	HPLC:The retention time of major peak of test solution should correspond to that of reference solution	Conforms
	IR:Sample spectrum corresponds to that of standard spectrum	Conforms
Appearance of solution	The solution is clear and not more intensely colored than reference solution BY6	Conforms
Related Substance	Avermectin NMT 2.0%	0.008
	Total impurities NMT 5.0%	0.039
Residual Solvents	Ethanol NMT 30000ppm	360ppm
	Acetone NMT 5000ppm	140ppm
BHT	NMT 2000ppm	316ppm
Sulphated Ash	NMT 0.1%	0.0007
Heavy Metal	NMT 200ppm	<20ppm
Water	NMT 3.0%	0.018
Assay(on anhydrous and solvent free basis)	≥95%	0.981

 

Doramectin Basic information

Pig antiparasitic Pharmacological effects Precautions

Product Name: Doramectin

Synonyms: DM/CBR15;25-CYCLOHEXYL-5-O-DEMETHYL-25-DE(1-METHYLPROPYL)AVERMECTIN;DORAMECTIN;Doramectin VETRANAL;Doromectin;25-Cclohexyl-avermectin B1;25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1A;Dectoma

CAS: 117704-25-3

MF: C50H74O14

MW: 899.11

EINECS: 601-490-4

Product Categories: -;Antiparasitic;Intermediates & Fine Chemicals;Pharmaceuticals;IMIPEM;Inhibitors;raw material-

Mol File: 117704-25-3.mol

 

Pharmacological effects

[Chemical properties] brown powder , very low solubility in water. 

Doramectin is used for the treatment of livestock diseases such as nematodes and mites ectoparasitosis,it is fermented by recombinant avermitilis (Streptomyces avermitilis) new strain, and the main difference from ivermectin is that C25 is substituted by cyclohexyl. It is a new, broad-spectrum antiparasitic drug,and is efficient for gastrointestinal nematodes, lung nematodes, Euglena, lice, ticks, mites and wound maggots , also has a good effect on internal and external parasites especially certain nematodes (round worms) and arthropods , but invalid to tapeworms, flukes and protozoa . Its mechanism of action is to increase the release of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) of the worm, thereby blocking the transmission of nerve signals, so that muscle cells lose their ability to contract, resulting in death of the parasites. the neurotransmitter of Peripheral nerves of mammals is acetylcholine,and will not be affected by Doramectin, doramectin cannot go through the blood-brain barrier easily , minimal damage to the central nervous system,safe to cattle. The main feature is that the plasma concentration and half-life are higher or twice than Ivermectin. The United States has approved to use as cattle, pigs and dedicated injection and cattle dedicated pour.

Precautions 1, doramectin is unstable and decomposes rapidly in the sunlight to be inactivated, its remnants of drugs are toxic to fish and aquatic organisms, so pay attention to water protection. 

2, pour-on: bovine application, not rain within 6 hours. 

3, use with caution in dogs.

4, the goods will be placed out of reach of children, the operator should not eat or smoking, wash hands after handling.

5, withdrawal period, 35 days of cattle, pigs 24 days.

Chemical Properties White Solid

Uses antibacterial

Uses Doramectin is a biosynthetic avermectin derived from a mutant strain of Streptomyces avermitilis, supplemented with a cyclohexylcaboxylic acid starting unit. Doramectin was developed as an anthelmintic for internal parasite control. The presence of the cyclohexyl group replacing the sec-butyl moiety affords greater hydrophobicity and longer biological half-life compared to avermectin. Like the other milbemycin/avermectins, it selectively binds to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite.

Uses A mutational biosynthetic antiparasitic antibiotic.

Uses Mutational biosynthetic antiparasitic antibiotic structurally related to the avermectins

Veterinary Drugs and Treatments Doramectin injection is indicated for the treatment and control of the following endo- and ectoparasites in cattle: roundworms (adults and some fourth stage larvae)-Ostertagia ostertagi (including inhibited larvae), O. lyrata, Haemonchus placei, Trichostrongylus axei, T. colubriformis, T. longispicularis, Cooperia oncophora, C. pectinata, C. punctata, C. surnabada (syn. mcmasteri), Bunostomum phlebotomum, Strongyloides papillosus, Oesophagostomum radiatum, Trichuris spp.; lungworms (adults and fourth stage larvae)-Dictyocaulus viviparus; eyeworms (adults)-Thelazia spp.; grubs (parasitic stages)-Hypoderma bovis, H. lineatum; lice-Haematopinus eurysternus, Linognathus vituli, Solenopotes capillatus; and mange mites-Psoroptes bovis, Sarcoptes scabiei.

In swine the injection is labeled for the treatment and control gastrointestinal roundworms (adults and 4th stage Ascaris suum, adults and 4th stage Oesophagostomum dentatum, Oesophagostomum quadrispinolatum adults, Strongyloides ransomi adults, and Hydrostrongylus rubidus adults), lungworms (Stephanurus dentatus adults), mange mites (adults and immature stages Sarcoptes scabeii var. suis), and sucking lice (adults and immature stages Haematopinus suis)

The manufacturer states the doramectin protects cattle against infection or reinfection with Ostertagia ostertagi for up to 21 days. Doramectin topical (pour-on) is approved for use in cattle and has a similar spectrum of action against a variety of endo- and ectoparasites, including biting lice.

Injectable doramectin has been used for treating a variety of nematode and arthropod parasites in companion animals, including generalized demodicosis in dogs and cats and spirocercosis in dogs.