Competitive Price C...

Competitive Price CAS 152044-53-6 Epothilone A,Epo A,Epothilones,Epothilon A

Competitive Price CAS 152044-53-6 Epothilone A,Epo A,Epothilones,Epothilon A

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1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: >99%
  • Payment Terms : L/C,T/T,

Keywords

CAS 152044-53-6 C26H39NO6S Epothilone A

Quick Details

  • Appearance:White powder
  • Application:Active pharmaceutical ingredients
  • PackAge:20kgs/drum
  • ProductionCapacity:300 |Metric Ton|Month
  • Storage:Cool Dry Place
  • Transportation:by sea or by aire

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Details:

Product information:

(-)-epothilone a basic information
product name: (-)-epothilone a
synonyms: 4,17-dioxabicyclo14.1.0heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1e)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (1s,3s,7s,10r,11s,12s,16r)-;epothilone-s;(1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-[(1e)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione;epothile;4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione,7,11-dihydroxy-8,8,10,12-tetramethyl-3- [(1e)-1-methy;ixabepilone impurity 5 (epothilone a);(1s,3s,7s,10r,11s,12s,16r,e)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione;(1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-[(1e)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione epothilone a
cas: 152044-53-6
mf: c26h39no6s
mw: 0
einecs:  
product categories: chiral reagents;inhibitors;intermediates & fine chemicals;pharmaceuticals;sulfur & selenium compounds
mol file: 152044-53-6.mol
(-)-epothilone a chemical properties  
mp 95ºC
density 1.143
storage temp. 20°c
safety information  
msds information  
(-)-epothilone a usage and synthesis  
usage the epothilones are a novel class of antineoplastic agents possessing antitubulin activity. epothilone a, b isolated from sorangium cellulosum was associated with cell cycle arrest at g2/m transition and apoptosis that was resisted with overexpression of β-tubulin and p-glycoprotein in human bladder carcinoma cell.
usage epothilone a is a microtubule inhibitor isolated from the myxobacteria, sorangium cellulosum. epothilone a acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the g2/m transition, leading to cytotoxicity. epothilone a has been investigated in clinical trials as an antitumour agent.
usage epothilone a is a microtubule inhibitor isolated from the myxobacteria, sorangium cellulosum. epothilone a acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the g2/m transition, leading to cytotoxicity. epothilone a has been investigated in clinical trials as an antitumor agent.


Specification:

 Category  Pharmaceutical Raw Materials, Fine Chemicals, Bulk drug
Standard Medical standard
Shelf life 2 years
 Storage  should be stored in a well-closed container at low temperature, keep away from moisture, heat and light.
Test Item Standard: USP 

Identification

IR spectrum similar to that of RS

HPLC retention time similar to that of RS

Related substance

Total impurities: NMT0.3%

Single impurity: NMT0.1%

Heavy metals

NMT 10ppm

Loss on drying

NMT0.5%

Residue on ignition

NMT0.1%

Assay

98.5%-101.0%



Product Description:

EpothiloneA was found in the celllosum of Myxobacteria Sorangiumcellulosum. It is a microtubule stabilizer similar to paclitaxel, which induces the polymerization of tubulin and leads to the cell cycle stopping at g2-M phase, which produces toxicity and also induces apoptosis. The EC0.01 value of EpothiloneA is 2μM. EpothiloneA effectively inhibited the proliferation of HCT116 cells with IC50 of 4.4nM. EpothiloneA acts on KB3-1,KBV-1,Hela, and Hs578T cells and has cytotoxic Chemicalbook with IC50 ranging from 13nM to 160nM. EpothiloneA is more water-soluble than paclitaxel, and it competitively binds to microtubules with IC50 of 2.3μM. However,EpothiloneA and Taxol do not share a pharmacophore, and they independently and specifically utilize their tubulin binding bags. The newly discovered Transformation of EpothiloneA caused by AspergillusnigerAS3.739 produced metabolites that were toxic to McF-7 cells but had very high IC50 values.

Product Application and Function:

Epothilone, a class of macrolides, was first reported by G. Hoffle et al., National Center for Biotechnology (GBF), Germany, in chemical Book 993. Ebomycin was isolated from the fermentation broth of the suborder Myxobacteria, cystis fibrinosa. The main components of ebomycin were EpothiloneA and B.

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