Pharmaceutical Raw Materials 99%min Crizotinib Manufacturer for Anti-Cancer CAS 877399-52-5

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10 Gram	Negotiable

10 Gram

Negotiable

Min.Order :10 Gram
Purity: >99%
Payment Terms : L/C,T/T,

Keywords

877399-52-5 Crizotinib C21H22Cl2FN5O

Quick Details

Appearance:white powder
Application: API intermediate
PackAge:25kg/Drum 1kg, 10kg, 100kg, 200kg
ProductionCapacity:100 |Kilogram|Day
Storage:Shady, sealed, dry place
Transportation:by sea or by air

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Details:

Product Name:Crizotinib
CAS:877399-52-5
MF:C21H22Cl2FN5O
MW:450.343
EINECS:638-814-9
Mol File:877399-52-5.mol
Melting point:192 °C
Boiling point:599.2±50.0 °C(Predicted)
Density 1.47±0.1 g/cm3(Predicted)
storage temp. room temp
pka9.81±0.10(Predicted)
form powder
color white to tan

Application:

Crizotinib is a dual ATP competitive inhibitor of tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50=8 nM) and ALK (cellular IC50=20 nM), both of which are important targets for cancer chemotherapy. When crizotinib was tested for selectivity versus other kinases it was found to have enzyme IC50's within 100-fold multiples of c-MET for 13 of the 120 kinases tested. In cellular assays, crizotinib was found to inhibit RON (recepteur d'origine nantais) kinase with a 10-fold selectivity window over c-MET.
Chemical PropertiesWhite Solid
UsesA potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). A potential antitumor agent.
UsesCrizotinib is a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.
UsesPF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectivley

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