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56-75-7 Chloramphenicol Levo C11H12Cl2N2O5
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Chloramphenicol is a broad spectrum antibiotic which inhibits translation on the 50S ribosomal subunit at the peptidyltransferase step.
Chloramphenicol is usually bacteristatic and effective against a wide range of gram-positive and gram-negative organisms.
Product name | Chloramphenicol | |
Shelf Life | 1 year | |
Items | Standard | Result |
Characters | A white, greyish-white or yellowish-white,fine,crystalline powder or fine | A yellowish-white,fine crystalline powder |
Slightly soluble in water,freely soluble in alcohol and in propylene glycol. Its alcohol solution is dextrorotatory and its ethyl acetate solution is levorotatory | Qualified | |
Identification | Melting point: 149°C?153°C | 149 C-152°C |
1R | Qualified | |
TLC | ||
Colar reaction | ||
Gives reaction of chlorides | ||
Acidity or alkalinity | Meets the requirements | Qualified |
Specific optical rotation | + 18.5° ?+20_5o | + 19.8° |
Related Substances | Individual impurity<0. 5% | Qualified |
Chlorides | < 0. 01% | Qualified |
Loss on drying | < 0. 5% | 0.10% |
Sulphated ash | < 0. 1% | 0.04% |
Assay | 98.0% ?102.0% | 99.7% |
Microbial limit | Bacteria Not more than 10 per g | Qualified |
Mold & yeast Absent per g | ||
Escherichia coli Absent per g | ||
Pseudomonas aeruginosa & staphylococcus aureus Absent per g | ||
Sterility | Complies | Qualified |
CONCLUSION: The product complies to the standard of BP2011. |
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