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D Examethasone Base Dexamethasone base C22H29FO5
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Product Introduction:
D Examethasone is a type of corticosteroid medication. It is used in the treatment of many conditions, including rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic obstructive lung disease, croup, brain swelling, and along with antibiotics in tuberculosis. In adrenocortical insufficiency, it should be used together with a medication that has greater mineralocorticoid effects such as fludrocortisone. In preterm labor, it may be used to improve outcomes in the baby. It may be taken by mouth, as an injection into a muscle, or intravenously. The effects of d examethasone are frequently seen within a day and last for about three days.
Product Functions&Applications:
Anti-inflammatory
D Examethasone is used to treat many inflammatory and autoimmune conditions, such as rheumatoid arthritis and bronchospasm. Idiopathic thrombocytopenic purpura, a decrease in numbers of platelets due to an immune problem, responds to 40 mg daily for four days; it may be administered in 14-day cycles. It is unclear whether d examethasone in this condition is significantly better than other glucocorticoids.
Cancer
People with cancer undergoing chemotherapy are often given d examethasone to counteract
certain side effects of their antitumor treatments. D Examethasone can increase the antiemetic effect of 5-HT3 receptor antagonists, such as ondansetron. The exact mechanism of this interaction is not well-defined, but it has been theorized that this effect may be due to, among many other causes, inhibition of prostaglandin synthesis, anti-inflammatory effects, immunosuppressive effects, or a combination of the aforementioned.
Endocrine
D Examethasone is the treatment for the very rare disorder of glucocorticoid resistance.
In adrenal insufficiency and Addison's disease, d examethasone is prescribed when the patient does not respond well to prednisone or methylprednisolone.
It can be used in congenital adrenal hyperplasia in older adolescents and adults to suppress ACTH production. It is typically given at night.
Pregnancy
D Examethasone may be given to women at risk of delivering prematurely to promote maturation of the fetus' lungs. This has been associated with low birth weight, although not with increased rates of neonatal death.
High-altitude illnesses
D Examethasone is used in the treatment of high-altitude cerebral edema (HACE), as well as high-altitude pulmonary edema (HAPE). It is commonly carried on mountain-climbing expeditions to help climbers deal with complications of altitude sickness.
Vomiting
D Examethasone and ondansetron are more effective than ondansetron alone in preventin postoperative nausea and vomiting.
Product | DEXAMETHASONE BASE | |
Shelf Life | 5 years | |
ITEM | SPECIFICATION | RESULT |
CHARACTER | WHITE OR ALMOST WHITE CRYSTALLINE POWDER | ALMOST WHITE CRYSTALLINE POWDER |
SPECIFIC ROTATION | +72° TO +80° | +76.2° |
IDENTIFICATION | (1)COMPLIES BY IR | CONFORMS |
(2)UV:△E/ERS ≤3.0% | 1.8% | |
TEST | ||
CHROMATOGRAPHIC PURITY | PRINCIPAL IMPURITY NOT MORE THAN 1.0% | 0.13% |
TOTAL IMPURITIES NOT MORE THAN 2.0% | 0.43% | |
LOSS ON DRYING | NOT MORE THAN 0.5% | 0.09% |
RESIDUE ON IGNITION | NOT MORE THAN 0.2% | 0.07% |
RESIDUAL SOLVENT | CHLOROFORM NOT MORE THAN 60ppm | NOT DETECTED |
METHANOL NOT MORE THAN 1000ppm | 220ppm | |
ETHYL ACETATE NOT MORE THAN 300ppm | 22ppm | |
ASSAY | CONTAINS 97.0% TO 102.0% OF C22H29FO5 CALCULATED ON DRIED BASIS | 100.1% |
CONCLUSION | THE PRODUCT CONFORMS TO USP39 |
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