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Pharmaceutical Raw Material CAS 15307-79-6 Diclofenac Sodium

Pharmaceutical Raw Material CAS 15307-79-6 Diclofenac Sodium

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1 Kilogram

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  • Min.Order :1 Kilogram
  • Purity: >99%
  • Payment Terms : L/C,T/T,

Keywords

15307-79-6 Diclofenac Sodium C14H10Cl2NNaO2

Quick Details

  • Appearance:White crystalline powder
  • Application:Diclofenac sodium has a effect on anti-inflammatory, analgesic and antipyretic.Diclofenac
  • PackAge:1-5KG/Tin or Bag,25KG/Drum, 200KG/Drum
  • ProductionCapacity:1000 |Kilogram|Year
  • Storage:Cool Dry Place
  • Transportation:by sea or by air

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Details:

Diclofenac sodium has a effect on anti-inflammatory, analgesic and antipyretic.Diclofenac Sodium is the salt form of diclofenac, an active metabolite of the NSAID aceclofenac (sc-217557). Hydrolysis of aceclofenac, an inhibitor of interleukin-1B-induced prostaglandin E2 production with no inhibitory activity against Cox (cyclooxygenase), generates diclofenac, an inhibitor of both Cox-1 and Cox-2. Oxidation of diclofenac produces the metabolite 4'-hydroxy diclofenac (sc-202423) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing antiinflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insolubleamyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9.

Product: DICLOFENAC SODIUM
Shelf Life 4 years
ITEMS SPECIFICATION RESULTS
Appearance A white or silightly yellowish crystalline powder White crystalline powder
Identification A.IR CONFORM
D.Test of sodium salt CONFORM
Appearance of solution The solution is clear and its absorbance at 440 nm is not greater than 0.05 Clear, 0.009
Related substances Impurity A:NMT0.2% <0.05%
Impurity F:NMT0.15% <0.05%
Any specified individual impurity:NMT0.10% <0.05%
Total impurities:NMT0.4% 0.069%
Heavy metals NMT 10 PPM <10ppm
Loss on drying NMT 0.5%(1g,105℃,3hrs) 0.04%
Assay 99.0~101.0%(dried substance) 100.2%
Conclusion:It accords with BP2015.Be up to the standard.

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