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50-23-7 Hydrocortisone C21H30O5
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Description
Hydrocortisone is the pharmaceutical term for cortisol used in oral administration, intravenous injection, or topical application. It is used as an immunosuppressive drug, given by injection in the treatment of severe allergic reactions such as anaphylaxis and angioedema, in place of prednisolone in patients needing steroid treatment but unable to take oral medication, and perioperatively in patients on long-term steroid treatment to prevent Addisonian crisis. It may also be injected into inflamed joints resulting from diseases such as gout.
It may be used topically for allergic rashes, eczema, psoriasis, itching and other inflammatory skin conditions.
Function & Application:
1. For adrenal insufficiency caused by disease, rheumatoid arthritis, rheumatic fever, gout, bronchial asthma. For atopic
dermatitis, seborrheic dermatitis, pruritus. Large doses cause Cushing's syndrome, sodium retention, psychiatric symptoms, digestive ulcers, osteoporosis, growth inhibition.
2. For iridocyclitis, keratitis, scleritis, conjunctivitis. For neurodermatitis, for tuberculous meningitis, pleurisy, arthritis,
tenosynovitis, acute and chronic sprain, strain, etc. sheath.
Product | HYDROCORTISONE BASE | |
Shelf Life | 3 years | |
ITEM | SPECIFICATION | RESULT |
CHARACTER | WHITE TO ALMOST WHITE CRYSTALLINE POWDER | ALMOST WHITE CRYSTALLINE POWDER |
IDENTIFICATION | (A)COMPLIES BY IR | CONFORMS |
(B)UV:△E/EES≤2.5% | 0.2% | |
TEST | ||
SPECIFIC ROTATION | +150° TO +156° | +153.0° |
LOSS ON DRYING | ≤1.0% | 0.3% |
RESIDUE ON IGNITION | ≤0.5% | 0.1% |
RELATED SUBSTANCES | INDIVIDUAL IMPURITY ≤0.5% | 0.28% |
TOTAL IMPURITIES ≤2.0% | 0.09% | |
RESIDUAL SOLVENT | CYCLOHEXANE ≤3880ppm | 2PPM |
METHANOL≤3000PPM | 82PPM | |
ASSAY |
CONTAINS 97.0% TO 102.0% OF C21H30O5 CALCULATED ON DRIED BASIS | 100.1% |
CONCLUSION: | THE PRODUCT CONFORMS TO USP38 AND CUSTOMER STANDARD. |
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