High Quality 99%Min...

High Quality 99%Min Purity Epalrestat CAS 82159-09-9

High Quality 99%Min Purity Epalrestat CAS 82159-09-9

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1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: >99%
  • Payment Terms : L/C,T/T,

Keywords

82159-09-9 C15H13NO3S2 Epalrestat

Quick Details

  • Appearance:yellow to orange, crystals or crystalline powder, discoloration and decomposition under light
  • Application:Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM .
  • PackAge:1-5KG/Tin or Bag,25KG/Drum, 200KG/Drum
  • ProductionCapacity:1000 |Metric Ton|Year
  • Storage:Cool Dry Place
  • Transportation:by sea or by air

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Details:

Describtion:

Epalrestat is the second aldose reductase inhibitor to be introduced worldwide and the first to be launched in Japan. The compound is indicated for the treatment of diabetic neuropathy. It is also being investigated for diabetic retinopathy and nephropathy.
Epalrestat is a non-competitive inhibitor of aldose reductase, which reversibly inhibits the conversion of glucose into aldose reductase of sorbitol in polyol metabolism related to the pathogenesis of diabetic complications. Significantly improve the patient's symptoms and neurological dysfunction, improve its motor nerve conduction speed and autonomic nerve function.

Usage:
An aldose reductase inhibitor. It is used in treatment of diabetic neuropathy.

Items Specifications Results
Appearance yellow to orange, crystals or crystalline powder, discoloration and decomposition under light Complies
Solubility soluble in N, N-dimethylformamide,slightly soluble in methanol and in ethanol (99.5), and practically insoluble in water. Complies
Melting Point 222~227℃ 222.5~225.0℃
Identification UV complies Complies
IR complies Complies
Related substance Single impurity ≤0.20% 0.04%
Total impurities ≤1.0% 0.06%
Residual solvent Alcohol ≤0.5% 0.06%
Tetrahydrofuran ≤0.072% 0.04%
Acetic acid ≤0.5% No detected
Loss on drying ≤0.2% 0.04%
Residue on ignition ≤0.1% 0.00%
Heavy metals ≤10ppm Complies
Particle size D50: 8~10μm 9.4μm
D90: 17~23μm 19.8μm
Assay on dried 98.0%~101.0% 100.50%
Conclusion Complies with the requirement of JP17
Containers and storage Containers—Tight containers Storage—Light-resistant

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