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CAS 53003-10-4 53003-10-4 Salinomycin
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Product information:
Product name: | salinomycin |
synonyms: | salinomycin sodium;salinomycin sodium salt;coxistac;salinomycin granule;salinomycin premix 12%;salinomycin from streptomyces albus;salinomycin 90%;sv sodium salt,2,5 salinomycin hydrate |
cas: | 53003-10-4 |
mf: | c42h69nao11 |
mw: | 772.98 |
product categories: | interferes with cell membrane permeability (ionophores)voltage-gated ion channels;ionophoresspectrum of activity;antibacterial;antibiotics;antibiotics a to;antibiotics n-santibiotics;chemical structure class;l - zantibiotics;mechanism of action;inhibitors |
mol file: | 53003-10-4.mol |
chemical properties | |
melting point | 112.5-113.5 °c(lit.) |
boiling point | 839.2 °c at 760 mmhg |
density | 1.18 g/cm3 |
flashing point | 243.2 °c |
vapor pressure | 1.04e-32 mmhg at 25 °c |
storage temp. | 2-8°c |
stability | stable, but may be heat sensitive - keep cool. incompatible with strong oxidizing agents. |
usage and synthesis | |
chemical properties | solid |
usage | antibacterial |
salinomycin is a polyether ionophore with broad spectrum gram positive and anti-coccidial activity. salinomycin has a high affinity for monovalent cations, particularly potassium. salinomycin is used to control coccidia in animals and for growth promotion in ruminants. recently, salinomycin has been shown to inhibit cancer stem cells and is >100 times more potent than taxol. while the mechanism of action is unknown, it was noted that among the 60,000 compounds screened, another monovalent ionophore, nigericin, and a chloride channel inhibitor, avermectin, were also active. |
Superiority
item |
standard |
result |
appearance |
brown yellow granules |
conform |
identification |
ethanol solution of the substance to be examined reacting with vanillin test solution shows red. |
positive reaction |
particle size |
not less than 95% pass through a 24 mesh sieve. |
100% |
loss on drying |
≤8.0% |
0.9% |
heavy metals |
≤0.0020% |
<0.0020% |
arsenic |
≤0.0002% |
<0.0002% |
salinomycin a |
≥85.0% |
94.2% |
related substances |
any single impurity≤5.0% |
conform |
total impurities≤10.0% |
5.8% |
|
assay |
potency for report only |
120u/mg |
90.0~110.0% |
100.0% |
|
conclusion |
this product conforms to in-house standard. |
Salinomycin is white powder. Freely soluble in acetone, trichloromethane, ethyl acetate, benzene, ether and methanol. Practically insoluble in water. Salinomycin is polyether ionophoric antibiotic having a unique tricyclic spiroketal ring system and an unsaturated 6-membered ring in the molecule, produced by microorganism fermentation and biochemical progress.
Function:
1.Salinomycin Sodium is an anti coccidiosis chemical medicine.It has a preventive effect on fowl Coccidiosis.
2.Salinomycin can change the content of volatile fatty acid in large intestine and kidney, so it also has the function of promoting the growth of chickens.
3.Salinomycin can improve the utility of crude protein, crude fatty acid, crude cellulose in feedstuff, thus it can improve the conversion ratio of feedstuff.
4. Salinomycin can control and reduce the number of intestinal pathogenic bacteria.
5. Salinomycin can reduce the production of microbial toxin, such as: biogenic amine and ammonia, etc.
6.Salinomycin can compete with animal nutrition in preventing intestine excessive breeding of microorganisms.
7. Salinomycin can regulate intestinal flora balance and improve the survival rate.
8. Salinomycin can control of chicken coccidiosis morbidity and mortality
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