Antihypertensive Dr...

Antihypertensive Drugs CAS 83915-83-7 Lisinopril Dihydrate

Antihypertensive Drugs CAS 83915-83-7 Lisinopril Dihydrate

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1 Kilogram

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Lisinopril 83915-83-7 Lisinopril Dihydrate

Quick Details

  • Appearance:white Powder
  • Application:Pharmaceutical intermediates
  • PackAge:1-5KG/Tin or Bag,25KG/Drum, 200KG/Drum
  • ProductionCapacity:1000 |Metric Ton|Year
  • Storage:Cool Dry Place
  • Transportation:by sea or by air

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Product description
Lisinopril is a third-generation angiotensin-converting enzyme inhibitor and a lysine derivative of enalapril. It was marketed in the United States in 1987 for the treatment of hypertension and is a first-line antihypertensive drug . The pharmacological action characteristics are similar to Enalapril (Enalapril), with strong angiotensin-converting enzyme inhibitory effect, quick onset and long action time, just take the medicine once a day. The inhibitory effect on ACE is 6 to 8 times that of captopril and 1 to 3 times that of benazepril.

Function and Application 
Angiotensin Converting Enzyme Inhibitor (ACE-I), a lysine derivative of Enalapril, is the third non-sulfhydryl group in the world to be marketed. ACE-I. Long-acting, once a day, and the dosage is only 1/20 of captopril, 1/4 of enalapril, oral bioavailability is better. The curative effect is remarkable. For moderate and severe patients, the Chemicalbook should be better than captopril and enalapril. It has no direct effect on the heart, does not cause arrhythmia, has no central effect, and has no adverse reactions such as blood pressure rebound. It can be used for diseases accompanied by diabetes, asthma, peripheral vascular disease, psychosis and congestive heart failure, and for other diseases Patients with hypertension who are contraindicated in the treatment of drugs. It is effective for short-term and long-term congestive heart failure.

Specification

Reference USP
Test Specification Results
Characters White crystalline powder. White crystalline powder.
Identification 1) Infrared absorption spectrum concordant with spectrum obtained with Lisinopril dihydrate RS. Conform
2) The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that of the Standard preparation obtained as directed in the Assay. Conform
Specific optical rotation [a]Hg25 -115.3-122.5° -119.6°
Water 8.0~9.5% 8.30%
Residue on ignition ≤0.1% <0.1%
Assay (HPLC) 98.0-102.0% (calculated on anhydrous basis) 98.60%
Residual solvents Ethanol≤0.5% 0.02%
Related substances (HPLC) DL-Homophenylalanine ≤0.30% <RL(RL:0.05%)
Related compound A ≤0.3% <RL(RL:0.05%)
R,S,S-Diketopiperazine ≤0.3% <LOD(LOD:0.01%)
Lisinopril epimer ≤0.3% 0.07%
Lisinopril cyclohexyl analogue ≤0.30% 0.08%
N-Alkyl-L-lysine ≤0.3% 0.09%
N-Alkyl lisinopril ≤0.15% <LOD(LOD:0.01%)
Any individual unspecified impurity≤0.10% <RL(RL:0.05%)
Total imp. does not include lisinopril epimer≤0.5% 0.17%
Conclusion Complies with USP

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