High Quality Lamivu...

High Quality Lamivudine Powder Price CAS 134678-17-4

High Quality Lamivudine Powder Price CAS 134678-17-4

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1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: >99%
  • Payment Terms : L/C,T/T,Other

Keywords

Lamivudine 134678-17-4 C8H11N3O3S

Quick Details

  • Appearance:white powder
  • Application:Immune & Anti-Fatigue
  • PackAge:1-5KG/Tin or Bag,25KG/Drum, 200KG/Drum
  • ProductionCapacity:1000 |Metric Ton|Year
  • Storage:Cool Dry Place
  • Transportation:by sea or by air

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Details:

Description

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor. Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV. It improves theseroconversion of e-antigen positive hepatitis B and also improves histology staging of the liver. Long term use of lamivudine unfortunately leads to emergence of a resistant hepatitis B virus (YMDD) mutant. Despite this, lamivudine is still used widely as it is well tolerated.

Specification
 

Items Tested Specification Results
Description A white or off-white crystall powder A white crystall powder
Solubility Soluble in water. Meets the requirements
Identification    
a). By HPLC The retention time of the major peak of the sample solution corresponds to that of the system suitability solution, as obtained in the test for limit of Lamivudine Enantiomer. Meets the requirements
b). By IR The infrared absorption of sample should exhibit maxima only at the same wavelengths as that of standard. Meets the requirements
Water by KF Not more than 0.2% 0.07%
Melting range Between 174.0ºC and 178.0ºC 176.8ºC~177.8ºC
Absorptivity Not more than 0.0015 0.0002
Related substances    
Lamivudine-carboxylic acid Not more than 0.3% 0.05%
Lamivudine diastereomer Not more than 0.2% 0.06%
Salicylic acid Not more than 0.1% Not detected
Any other individual impurity Not more than 0.1% 0.03%
Total impurities Not more than 0.6% 0.15%
Limit of Lamivudine Enantiomer Not more than 0.3% 0.01%
Assay Between 98.0% and 102.0% on anhydrous and solvent-free basis. 100%
Limit of residual solvents    
Alcohol Not more than 0.2% Not detected
Isopropyl acetate Not more than 0.2% Not detected
Methanol Not more than 0.1% Not detected
Triethylamine Not more than 0.1% Not detected
Isopropyl alcohol* Not more than 0.5% 0.16%
Ethyl acetate * Not more than 0.5% Not detected
Toluene* Not more than 0.089% Not detected
Dichloromethane* Not more than 0.06% Not detected
Normal hexane * Not more than 0.029% Not detected
DMF* Not more than 0.088% Not detected
Total residual solvents Not more than 0.3% 0.16%
Remark:*The solvents are used in the manufacturing process of lamivudine besides those listed in usp41.

 

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