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Levofloxacin Hemihydrate 100986-85-4 levofloxacin
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Product Name: | Levofloxacin hydrochloride |
Synonyms: | (s)-ofloxacin;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (S)-;Cravit;HR 355;Levaquin;RWJ 25213-097;Tavanic;(-)-(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazin-yl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid |
CAS: | 100986-85-4 |
MF: | C18H20FN3O4 |
MW: | 361.37 |
EINECS: | 600-146-0 |
Levofloxacin, one of the quinolones, has a broad spectrum of antimicrobial action.It has strong antibacterial activity against most Enterobacteriaceae bacteria, such as Escherichia coli, Klebsiella, Proteobacteria, Salmonella, Shigella and Gram-negative bacteria such as Haemophilus influenzae, Legionella pneumophila and Neisseria gonorrhoeae.It also has antibacterial effect on Gram-positive bacteria such as Staphylococcus aureus, Streptococcus pneumoniae and Streptococcus pyogenes, Mycoplasma pneumoniae and Chlamydia pneumoniae, but it has poor effect on anaerobic bacteria and Enterococcus
Function and Application
This product has the characteristics of strong antibacterial spectrum, antibacterial effect, for the majority of enterobacteriaceae bacteria, such as pneumonia klebsiella white fungus, proteus, typhoid salmonella, shigella, influenza bacillus, part of escherichia coli, pseudomonas aeruginosa, neisseria gonorrhoeae and so on have strong antibacterial activity, for part of staphylococcus aureus, streptococcus pneumoniae, chlamydia, also have good antibacterial effect.
Specification
Items | Standards | Results | |
Appearance | White or off-white solid powder | Complies | |
Identification | By IR | Complies | |
By HPLC | Complies | ||
Solubility | Soluble in DMF, sparingly soluble in THF, slightly soluble in methanol and acetonitrile, very sightly soluble in ethanol and dichloromethane, insoluble in water | Complies | |
Polymorphic Form | Polymorphic form 1 | Complies | |
Melting Point | 211ºC~216ºC | 212.8ºC~214.9ºC | |
Water Content | ≤ 0.50% | 0.10% | |
Heavy Metals | ≤ 20ppm | Complies | |
Residue on Ignition | ≤ 0.20% | 0.09% | |
Related Substance | Any single impurity: ≤0.10% | 0.06% | |
Total Impurities: ≤1.00% | 0.16% | ||
Assay (on the anhydrous basis) | 98.0%~102.0% | 99.94% | |
Particle Size | D90: ≤100µm | Complies | |
Reference Standard | In-house Standard | ||
Conclusion | The product complied to In-house standard. |
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